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Corralling a protein-degradation regulator

Nature volume 512, pages 145146 (14 August 2014) | Download Citation

The crystal structure of the COP9 signalosome, a large protein complex that regulates intracellular protein degradation, reveals how the complex achieves exquisite specificity for its substrates. See Article p.161

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Author information

Affiliations

  1. Raymond J. Deshaies is in the Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.

    • Raymond J. Deshaies

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Correspondence to Raymond J. Deshaies.

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https://doi.org/10.1038/nature13644

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