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Keeping one's sex

Progeny of the protist Paramecium tetraurelia always retain the parental mating type. This inheritance is revealed to result from an RNA-guided DNA-deletion pathway that protects the genome from foreign DNA sequences. See Article p.447

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Figure 1: Epigenetic inheritance of mating type.


  1. Sonneborn, T. M. Adv. Genet. 1, 263–358 (1947).

    Article  CAS  Google Scholar 

  2. Singh, D. P. et al. Nature 509, 447–452 (2014).

    Article  ADS  CAS  Google Scholar 

  3. Arnaiz, O. et al. PLoS Genet. 8, e1002984 (2012).

    Article  CAS  Google Scholar 

  4. Lepère, G., Bétermier, M., Meyer, E. & Duharcourt, S. Genes Dev. 22, 1501–1512 (2008).

    Article  Google Scholar 

  5. Malone, C. D. & Hannon, G. J. Cell 136, 656–668 (2009).

    Article  CAS  Google Scholar 

  6. Josse, T. et al. PLoS Genet. 3, 1633–1643 (2007).

    Article  CAS  Google Scholar 

  7. Ashe, A. et al. Cell 150, 88–99 (2012).

    Article  CAS  Google Scholar 

  8. Lee, H.-C. et al. Cell 150, 78–87 (2012).

    Article  CAS  Google Scholar 

  9. Shirayama, M. et al. Cell 150, 65–77 (2012).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Douglas L. Chalker.

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Chalker, D. Keeping one's sex. Nature 509, 430–431 (2014).

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