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Retraction Note: The NAD-dependent deacetylase SIRT2 is required for programmed necrosis


The Original Article was published on 28 November 2012

Nature 492, 199–204 (2012); doi:10.1038/nature11700

We retract this Article because some of the data, specifically the data reported in Fig. 2 demonstrating an in vitro requirement for Sirt2 in TNF-α-mediated necroptosis, appears to be irreproducible. We and others have confirmed that Sirt2 and RIP3 interact, and we continue to believe that the absence of Sirt2 protects against ischaemic myocardial damage. Nonetheless, our inability to reproduce the data in Fig. 2 involving TNF-α-mediated necroptosis undermines our confidence in the scientific conclusions reported and the proposed mechanism. Although the matter is currently under further review, we wish to retract the Article in its entirety, and regret any adverse consequences that may have resulted from the paper’s publication.


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The online version of the original article can be found at 10.1038/nature11700

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Narayan, N., Lee, I., Borenstein, R. et al. Retraction Note: The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature 506, 516 (2014).

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