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Developmental neuroscience

Miniature human brains

A study shows that stem cells can be used to generate self-organizing three-dimensional tissues that mimic the developing human brain. These tissues provide a tool for modelling neurodevelopmental disorders. See Article p.373

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Figure 1: Organoid generation from human pluripotent stem cells.
Figure 2: A detailed view.


  1. *This article and the paper under discussion1 were published online on 28 August 2013.


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Correspondence to Oliver Brüstle.

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Brüstle, O. Miniature human brains. Nature 501, 319–320 (2013).

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