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Structural biology

Active arrestin proteins crystallized

Arrestin proteins regulate cellular signalling cascades initiated by ubiquitous G-protein-coupled receptors. Crystal structures reveal that two arrestins undergo similar structural changes on activation. See Letters p.137 & p.142

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Figure 1: Comparison of inactive and active arrestins.

Notes

  1. 1.

    *This article and the papers under discussion1,2 were published online on 24 April 2013.

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Correspondence to Georg Büldt.

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NOBEL 2012 Chemistry: Studies of a ubiquitous receptor family

https://doi.org/10.1038/11634

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Borshchevskiy, V., Büldt, G. Active arrestin proteins crystallized. Nature 497, 45–46 (2013). https://doi.org/10.1038/nature12096

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