Nature 491, 608–612 (2012); doi:10.1038/nature11536

On page 610 of this Letter, the overview comments concerning the action of ATP synthase should read: “Under physiological conditions, the F1F0-ATP synthase generates ATP by consuming the proton motive force existing across the inner mitochondrial membrane, transporting H+ ions from the intermembrane space into the mitochondrial matrix8,15. When respiration is inhibited or the mitochondrial membrane potential (ΔΨm) is decreased, the F1F0-ATP synthase reverses the direction of H+ transport, dissipating ATP in the attempt to maintain the proton motive force8,15. Under these conditions, Atpif1 inhibits the reversal of the F1F0-ATP synthase to decrease ATP hydrolysis, thereby counteracting the maintenance of the mitochondrial membrane potential (ΔΨm) and proton motive force8”. This rewording has no effect on the data, the scientific interpretation and the resulting model presented, and has been corrected in the HTML and PDF versions of the original paper.