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Angelman syndrome

Drugs to awaken a paternal gene

Mutations in the maternal copy of the UBE3A gene cause a neurodevelopmental disorder known as Angelman syndrome. Drugs that activate the normally silenced paternal copy of this gene may be of therapeutic value. See Letter p.185

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Figure 1: Differential regulation of maternal and paternal UBE3A.


  1. *This article and the paper1 under discussion were published online on 21 December 2011.


  1. Huang, H.-S. et al. Nature 481, 185–189 (2011).

    ADS  Article  Google Scholar 

  2. Guy, J., Gan, J., Selfridge, J., Cobb, S. & Bird, A. Science 315, 1143–1147 (2007).

    ADS  CAS  Article  Google Scholar 

  3. Weeber, E. J. et al. J. Neurosci. 23, 2634–2644 (2003).

    CAS  Article  Google Scholar 

  4. Gammon, D. C. et al. Am. J. Health-Syst. Pharm. 63, 2083–2086 (2006).

    CAS  Article  Google Scholar 

  5. Bird, L. M. et al. Am. J. Med. Genet. A 155, 2956–2963 (2011).

    ADS  CAS  Article  Google Scholar 

  6. Williams, C. A., Driscoll, D. J. & Dagli, A. I. Genet. Med. 12, 385–395 (2010).

    CAS  Article  Google Scholar 

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Correspondence to Arthur L. Beaudet.

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Beaudet, A. Drugs to awaken a paternal gene. Nature 481, 151–152 (2012).

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