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Des Marais & Rausher reply

Nature volume 462, pages E2–E3 (2009)Cite this article

Abstract

Replying to: T. Barkman & J. Zhang Nature 462, 10.1038/nature08663 (2009)

Barkman and Zhang1 level two criticisms at our report of escape from adaptive conflict (EAC)2. The first criticism is that our evidence of repeated adaptive substitution in the DFR-A/C lineage is consistent with either EAC or neofunctionalization in that lineage. As indicated in our original report2, we do not disagree with this claim, but believe it misses the point that the hallmark of EAC is the adaptive improvement of function in both duplicate lineages. The repeated positive selection in the DFR-A/C lineage simply demonstrates improvement of some as yet unspecified function in that lineage.

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Figure 1: Product production on different substrates relative to DHM production.

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References

  1. Barkman, T. & Zhang, J. Evidence for escape from adaptive conflict? Nature 462 10.1038/nature08663 (2009)

  2. Des Marais, D. L. & Rausher, M. D. Escape from adaptive conflict after duplication in an anthocyanin pathway gene. Nature 454, 762–765 (2008)

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  3. Eich, E. Solanaceae and Convolvulaceae: Secondary Metabolites Ch. 6 (Springer, 2008)

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  4. Shimada, N. et al. A comprehensive analysis of six dihydroflavonol 4-reductases encoded by a gene cluster of the Lotus japonicus genome. J. Exp. Bot. 56, 2573–2585 (2005)

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Author notes

  1. David L. Des Marais

    Present address: Present address: Section of Integrative Biology, The University of Texas at Austin, 1 University Station C0930, Austin, Texas 78712, USA,

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  1. Department of Biology and University Program in Genetics and Genomics, Box 90338, Duke University, Durham, Carolina 27708-0338, North, USA

    David L. Des Marais & Mark D. Rausher

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  1. David L. Des Marais
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  2. Mark D. Rausher
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Des Marais, D., Rausher, M. Des Marais & Rausher reply . Nature 462, E2–E3 (2009). https://doi.org/10.1038/nature08664

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