Article

Lateral presynaptic inhibition mediates gain control in an olfactory circuit

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Abstract

Olfactory signals are transduced by a large family of odorant receptor proteins, each of which corresponds to a unique glomerulus in the first olfactory relay of the brain. Crosstalk between glomeruli has been proposed to be important in olfactory processing, but it is not clear how these interactions shape the odour responses of second-order neurons. In the Drosophila antennal lobe (a region analogous to the vertebrate olfactory bulb), we selectively removed most interglomerular input to genetically identified second-order olfactory neurons. Here we show that this broadens the odour tuning of these neurons, implying that interglomerular inhibition dominates over interglomerular excitation. The strength of this inhibitory signal scales with total feedforward input to the entire antennal lobe, and has similar tuning in different glomeruli. A substantial portion of this interglomerular inhibition acts at a presynaptic locus, and our results imply that this is mediated by both ionotropic and metabotropic receptors on the same nerve terminal.

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Acknowledgements

We thank K. Ito, L. Luo, G. Roman, D. P. Smith, L. M. Stevens and L. B. Vosshall for gifts of fly stocks. We thank G. Laurent, A. W. Liu and members of the Wilson laboratory for conversations. This work was funded by a grant from the NIDCD, the Pew, McKnight, Sloan, and Beckman Foundations (to R.I.W.). S.R.O. was partially supported by a NSF fellowship.

Author Contributions S.R.O. performed the experiments and analysed the data. S.R.O. and R.I.W. designed the experiments and wrote the paper.

Author information

Affiliations

  1. Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA

    • Shawn R. Olsen
    •  & Rachel I. Wilson

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  1. Search for Shawn R. Olsen in:

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Corresponding author

Correspondence to Rachel I. Wilson.

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