Article | Published:

Genome-wide association study identifies novel breast cancer susceptibility loci

Nature volume 447, pages 10871093 (28 June 2007) | Download Citation

This article has been updated

Abstract

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less than 25% of the familial risk of breast cancer, and the residual genetic variance is likely to be due to variants conferring more moderate risks. To identify further susceptibility alleles, we conducted a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls, followed by a third stage in which 30 single nucleotide polymorphisms (SNPs) were tested for confirmation in 21,860 cases and 22,578 controls from 22 studies. We used 227,876 SNPs that were estimated to correlate with 77% of known common SNPs in Europeans at r2 > 0.5. SNPs in five novel independent loci exhibited strong and consistent evidence of association with breast cancer (P < 10-7). Four of these contain plausible causative genes (FGFR2, TNRC9, MAP3K1 and LSP1). At the second stage, 1,792 SNPs were significant at the P < 0.05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach.

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Change history

  • 28 June 2007

    In the AOP version of this Article, Kristy Driver was omitted from The SEARCH collaborators. This and the Supplementary Information acknowledgements have now been corrected for both print and online publication on 28 June 2007.

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Acknowledgements

The authors thank the women who took part in this research, and all the funders and support staff who made this study possible. The principal funding for this study was provided by Cancer Research UK. Detailed acknowledgements are provided in Supplementary Information.

Author Contributions D.F.E., A.M.D., P.D.P.P., D.R.C. and B.A.J.P. designed the study and obtained financial support. D.G.B. and D.R.C. directed the genotyping of stages 1 and 2. D.F.E. and D.T. conducted the statistical analysis. K.A.P. and A.M.D. coordinated the genotyping for stage 3 and the fine-scale mapping of the FGFR2 and TNRC9 loci. J.P.S. and J.Z. performed resequencing and analysis of the FGFR2 locus. K.A.P., S.A., C.S.H., R.B., C.A.H., L.K.K., B.E.H., L.L.M., P.B., S.S., V.G., F.O., C-Y. S., P-E.W. and H-C.W. conducted genotyping for the fine-scale mapping. R.L., J.M., H.F. and K.B.M. provided bioinformatics support. D.E., D.G.E., J.P., O.F., N.J., S.S., M.R.S. and N.R. coordinated the studies used in stage 1. N.W. and N.E.D. coordinated the EPIC study used in stages 1 and 2. The remaining authors coordinated the studies in stage 3 and undertook genotyping in those studies. D.F.E. drafted the manuscript, with substantial contributions from K.A.P., A.M.D., P.D.P.P. and B.A.J.P. All authors contributed to the final paper.

Author information

Affiliations

  1. CR‐UK Genetic Epidemiology Unit, Department of Public Health and Primary Care and,

    • Douglas F. Easton
    •  & Deborah Thompson
  2. Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.

    • Karen A. Pooley
    • , Alison M. Dunning
    • , Paul D. P. Pharoah
    • , Jonathan Morrison
    • , Helen Field
    • , Shahana Ahmed
    •  & Catherine S. Healey
  3. Perlegen Sciences, Inc., 2021 Stierlin Court, Mountain View, California 94043, USA.

    • Dennis G. Ballinger
  4. Laboratory of Population Genetics, US National Cancer Institute, Bethesda, Maryland 20892, USA.

    • Jeffery P. Struewing
    •  & Jinghui Zhang
  5. EPIC, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.

    • Robert Luben
    •  & Nicholas Wareham
  6. MRC Dunn Clinical Nutrition Centre, Cambridge CB2 0XY, UK.

    • Richard Bowman
  7. Cancer Research UK Cambridge Research Institute, Cambridge CB2 0RE, UK.

    • Kerstin B. Meyer
  8. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.

    • Christopher A. Haiman
    •  & Brian E. Henderson
  9. Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA.

    • Laurence K. Kolonel
    •  & Loic Le Marchand
  10. International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon 69008, France.

    • Paul Brennan
    • , Valerie Gaborieau
    •  & Fabrice Odefrey
  11. National Cancer Institute, Bangkok 10400, Thailand.

    • Suleeporn Sangrajrang
  12. Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.

    • Chen-Yang Shen
    • , Pei-Ei Wu
    •  & Hui-Chun Wang
  13. Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton SO16 5YA, UK.

    • Diana Eccles
  14. Regional Genetic Service, St Mary’s Hospital, Manchester M13 0JH, UK.

    • D. Gareth Evans
  15. London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK, and Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

    • Julian Peto
  16. Breakthrough Breast Cancer Research Centre, London SW3 6JB, UK.

    • Olivia Fletcher
    •  & Nichola Johnson
  17. Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK.

    • Sheila Seal
    • , Michael R. Stratton
    •  & Nazneen Rahman
  18. Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

    • Michael R. Stratton
  19. Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia.

    • Georgia Chenevix-Trench
    • , Amanda B. Spurdle
    • , Jonathan Beesley
    •  & Xiaoqing Chen
  20. Departments of Clinical Biochemistry and

    • Stig E. Bojesen
    •  & Børge G. Nordestgaard
  21. Breast Surgery, Herlev and Bispebjerg University Hospitals, University of Copenhagen, DK‐2730 Herlev, Denmark.

    • Christen K. Axelsson
  22. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA.

    • Montserrat Garcia-Closas
    •  & Louise Brinton
  23. Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland 20877, USA.

    • Stephen Chanock
  24. Cancer Center and M. Sklodowska‐Curie Institute of Oncology, Warsaw 02781, Poland.

    • Jolanta Lissowska
  25. Nofer Institute of Occupational Medicine, Lodz 90950, Poland.

    • Beata Peplonska
  26. Departments of Obstetrics and Gynecology, and

    • Heli Nevanlinna
    • , Rainer Fagerholm
    •  & Hannaleena Eerola
  27. Department of Oncology, Helsinki University Central Hospital, Helsinki 00029, Finland.

    • Hannaleena Eerola
  28. Seoul National University College of Medicine, Seoul 151‐742, Korea.

    • Daehee Kang
    • , Keun-Young Yoo
    •  & Dong-Young Noh
  29. National Cancer Center, Goyang 411‐769, Korea.

    • Keun-Young Yoo
  30. Ulsan University College of Medicine, Ulsan 680‐749, Korea.

    • Sei-Hyun Ahn
  31. Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Ave., Boston, Massachusetts 02115, USA.

    • David J. Hunter
    •  & David G. Cox
  32. Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Ave., Boston, Massachusetts 02115, USA.

    • David J. Hunter
    •  & Susan E. Hankinson
  33. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm SE‐171 77, Sweden.

    • Per Hall
    •  & Sara Wedren
  34. Population Genetics, Genome Institute of Singapore, 60 Biopolis Street, Singapore 138672, Republic of Singapore.

    • Jianjun Liu
    •  & Yen-Ling Low
  35. Department of Radiation Oncology and

    • Natalia Bogdanova
  36. Department of Gynecology and Obstetrics, Hannover Medical School, D‐30625 Hannover, Germany.

    • Natalia Bogdanova
    • , Peter Schürmann
    •  & Thilo Dörk
  37. Department of Surgery and

    • Rob A. E. M. Tollenaar
  38. Department of Medical Decision Making and

    • Catharina E. Jacobi
  39. Departments of Human Genetics and Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.

    • Peter Devilee
  40. Family Cancer Clinic, Department of Medical Oncology, Erasmus MC‐Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA Rotterdam, the Netherlands.

    • Jan G. M. Klijn
  41. Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892, USA.

    • Alice J. Sigurdson
    •  & Michele M. Doody
  42. Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA.

    • Bruce H. Alexander
  43. Institute for Cancer Studies and

    • Angela Cox
    • , Ian W. Brock
    •  & Gordon MacPherson
  44. Academic Unit of Surgical Oncology, Sheffield University Medical School, Sheffield S10 2RX, UK.

    • Malcolm W. R. Reed
  45. Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

    • Fergus J. Couch
    • , Ellen L. Goode
    •  & Janet E. Olson
  46. VU University Medical Center, 1007 MB Amsterdam, the Netherlands.

    • Hanne Meijers-Heijboer
  47. Department of Clinical Genetics and

    • Hanne Meijers-Heijboer
    •  & Ans van den Ouweland
  48. Internal Medicine, Erasmus University, Rotterdam NL‐3015‐GE, the Netherlands.

    • André Uitterlinden
    •  & Fernando Rivadeneira
  49. Spanish National Cancer Centre (CNIO), Madrid E‐28029, Spain.

    • Roger L. Milne
    • , Gloria Ribas
    • , Anna Gonzalez-Neira
    •  & Javier Benitez
  50. Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, University of Melbourne, Carlton, Victoria 3053, Australia.

    • John L. Hopper
    •  & Melissa Southey
  51. Department of Preventive and Social Medicine, University of Otago, Dunedin 9001, New Zealand.

    • Margaret McCredie
  52. Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Victoria 3053, Australia.

    • Graham G. Giles
  53. Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria 3052, Australia.

    • Chris Schroen
  54. Dr. Margarete Fischer‐Bosch‐Institute of Clinical Pharamcology, 70376 Stuttgart and University of Tuebingen, 72074 Tuebingen, Germany.

    • Christina Justenhoven
    •  & Hiltrud Brauch
  55. Deutsches Krebsforschungszentrum, Heidelberg 69120, Germany.

    • Ute Hamann
  56. Evangelische Kliniken Bonn gGmbH Johanniter Krankenhaus, 53113 Bonn, Germany.

    • Yon-Dschun Ko
  57. Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia.

  58. Insitute of Clinical Medicine, Pathology and Forensic Medicine, University of Kuopio, Kuopio FIN‐70210, Finland.

  59. Departments of Oncology and Pathology, University Hospital of Kuopio, Kuopio FIN‐70211, Finland.

  60. Department of Oncology, Vaasa Central Hospital, Vaasa 65130, Finland.

  61. Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.

    • Craig Luccarini
    • , Don Conroy
    • , Mitul Shah
    • , Hannah Munday
    • , Clare Jordan
    • , Barbara Perkins
    • , Judy West
    • , Karen Redman
    •  & Kristy Driver
  62. Oncology Research Centre, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.

    • Morteza Aghmesheh
    •  & Bruce A. J. Ponder
  63. Genetic Health Services Victoria, Royal Children’s Hospital, Melbourne, Victoria 3050, Australia.

    • David Amor
    •  & David R. Cox
  64. Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.

    • Lesley Andrews
    • , Barbara Bennett
    • , Bettina Meiser
    • , Kathy Tucker
    •  & Janet Tyler
  65. Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia.

    • Yoland Antill
    • , Sarah-Jane Dawson
    • , Kelly Phillips
    • , Clare Scott
    •  & Nicholas E. Day
  66. Anatomical Pathology, Royal Women’s Hospital, Carlton, Victoria 3053, Australia.

    • Jane Armes
  67. Molecular Genetics Laboratory, Royal Brisbane and Women’s Hospital, Herston, Queensland 4029, Australia.

    • Shane Armitage
    • , Leanne Arnold
    • , Alison Jones
    •  & Bruce A. J. Ponder
  68. Departments of Translational and Medical Oncology, Westmead Hospital, Westmead, New South Wales 2145, Australia.

    • Rosemary Balleine
  69. Cancer Biology Laboratory, TVW Institute for Child Health Research, Subiaco, Western Australia 6008, Australia.

    • Glenn Begley
  70. Pathology Centre, Queen Elizabeth Medical Centre, Nedlands, Western Australia 6009, Australia.

    • John Beilby
  71. Silverton Place, 101 Wickham Terrace, Brisbane, Queensland 4000, Australia.

    • Ian Bennett
  72. Department of Public Health and Community Medicine, University of Sydney, Sydney, New South Wales 2006, Australia.

    • Geoffrey Berry
  73. John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australian Capital Territory 2601, Australia.

    • Anneke Blackburn
  74. NSW Breast Cancer Institute, PO Box 143, Westmead, New South Wales 2145, Australia.

    • Meagan Brennan
  75. Department of Biochemistry, University of Queensland, St. Lucia, Queensland 4072, USA.

    • Melissa Brown
  76. Molecular and Cytogenetics Unit, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.

    • Michael Buckley
  77. Royal Hobart Hospital, GPO Box 1061L, Hobart, Tasmania 7001, Australia.

    • Jo Burke
    •  & Evelyn Humphrey
  78. Medical Psychology Unit, Royal Prince Alfred Hospital, Camperdown, New South Wales 2204, Australia.

    • Phyllis Butow
  79. Australian Genome Research Facility, Walter & Eliza Hall Medical Research Institute, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.

    • Keith Byron
  80. Dame Roma Mitchell Cancer Research Laboratories, University of Adelaide/Hanson Institute, PO Box 14, Rundle Mall, South Australia 5000, Australia.

    • David Callen
  81. Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Victoria 3002, Australia.

    • Ian Campbell
    • , Joe Sambrook
    •  & Heather Thorne
  82. Queensland Institute of Medical Research, Herston, Queensland 4006, Australia.

    • Georgia Chenevix-Trench
    • , Nick Hayward
    • , Amanda Spurdle
    • , Adele Green
    •  & Penny Webb
  83. Westmead Institute for Cancer Research, University of Sydney, Westmead Hospital ,Westmead, New South Wales 2145, Australia.

    • Christine Clarke
    •  & Graham Mann
  84. Department of Clinical Genetics, Liverpool Health Service, PO Box 103, Liverpool, New South Wales 2170, Australia.

    • Alison Colley
  85. Mutation Research Centre, St Vincent’s Hospital, Victoria Parade, Fitzroy, Victoria 3065, Australia.

    • Dick Cotton
  86. Centre for Genetic Epidemiology, The University of Melbourne, Level 2 723 Swanston Street, Carlton, Victoria 3053, Australia.

    • Jisheng Cui
    • , Roger Milne
    •  & Melissa Southey
  87. Molecular and Clinical Genetics, Level 1 Building 65, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia.

    • Bronwyn Culling
  88. Department of Pathology, University of Queensland Medical School, Herston, New South Wales 4006, Australia.

    • Margaret Cummings
  89. Central Regional Genetic Services, Wellington Hospital, Private bag 7902, Wellington South 6039, New Zealand.

    • Joanne Dixon
  90. Molecular Department of Pathology, Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Victoria 3002, Australia.

    • Alexander Dobrovic
    •  & Paul Waring
  91. Hunter Genetics, Hunter Area Health Service, Waratah, New South Wales 2310, Australia.

    • Tracy Dudding
    •  & Rodney Scott
  92. Clinical Chemistry, Princess Margret Hospital for Children, Box D184, Perth, Western Australia 6001, Australia.

    • Ted Edkins
  93. Department of Multicultural Health, University of Sydney, New South Wales 2052, Australia.

    • Maurice Eisenbruch
  94. Tissue Pathology, Institute of Medical & Veterinary Science, Adelaide, South Australia 5000, Australia.

    • Gelareh Farshid
  95. Family Cancer Clinic, Monash Medical Centre, Clayton, Victoria 3168, Australia.

    • Susan Fawcett
  96. Faculty of Medicine, Royal North Shore Hospital, Vindin House, St Leonards, New South Wales 2065, Australia.

    • Michael Field
  97. Department of Haematology, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia.

    • Frank Firgaira
    • , Scott Grist
    •  & Ram Seshadri
  98. Eskitis Institute of Cell & Molecular Therapies, School of Biomolecular and Biomedical Sciences, Griffith University, Nathan, Queensland 4111, Australia.

    • Jean Fleming
  99. Surgical Oncology, University of Newcastle, Newcastle Mater Hospital, Waratah, New South Wales 2298, Australia.

    • John Forbes
  100. Department of Medical Oncology, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.

    • Michael Friedlander
  101. Victorian Clinical Genetics Service, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia.

    • Clara Gaff
    •  & Mac Gardner
  102. Queensland Clinical Genetic Service, Royal Children’s Hospital, Bramston Terrace, Herston, Queensland 4020, Australia.

    • Mike Gattas
  103. Clinical Biochemistry Unit, Canterbury Health Labs, PO Box 151, Christchurch 8140, New Zealand.

    • Peter George
  104. Cancer Epidemiology Centre, The Cancer Council Victoria, 1 Rathdowne Street, Carlton, Victoria 3053, Australia.

    • Graham Giles
  105. Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia.

    • Grantley Gill
  106. Genetic Services of WA, King Edward Memorial Hospital, 374 Bagot Road, Subiaco, Western Australia 6008, Australia.

    • Jack Goldblatt
    • , Sharron Townshend
    •  & Ian Walpole
  107. Wollongong Hereditary Cancer Clinic, Wollongong Public Hospital, Private Mail Bag 8808, South Coast Mail Centre, New South Wales 2521, Australia.

    • Sian Greening
  108. Department of Medical Genetics, Women’s and Children’s Hospital, North Adelaide, South Australia 5006, Australia.

    • Eric Haan
    •  & Graeme Suthers
  109. Familial Cancer Clinic, Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Victoria 3002, Australia.

    • Marion Harris
    • , Michael McKay
    • , Gillian Mitchell
    •  & Mary Ann Young
  110. Breast and Ovarian Cancer Genetics, Monash Medical Centre, 871 Centre Road, Bentleigh East, Victoria 3165, Australia.

    • Stewart Hart
  111. Centre for Molecular Environmental, Genetic & Analytic Epidemiology, University of Melbourne, Melbourne, Victoria 3010, Australia.

    • John Hopper
    • , Richard Osborne
    •  & Dorota Gertig
  112. School of Population Health, The University of Melbourne, 723 Swanston Street, Carlton, Victoria 3053, Australia.

    • Mark Jenkins
  113. Medical Oncology, Westmead Hospital, Westmead, New South Wales 2145, Australia.

    • Rick Kefford
  114. Familial Cancer Service, Department of Medicine, Westmead Hospital, Westmead, New South Wales 2145, Australia.

    • Judy Kirk
    •  & Jennifer Leary
  115. Breast Endocrine and Surgical Unit, Royal Adelaide Hospital, North Terrace, South Australia 5000, Australia.

    • James Kollias
  116. Molecular Pathology Department, Southern Cross Pathology, Monash Medical Centre, Clayton, Victoria 3168, Australia.

    • Sergey Kovalenko
  117. Molecular and Cellular Pathology, The University of Queensland, Herston, Queensland 4006, Australia.

    • Sunil Lakhani
  118. Department of Psychological Medicine, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia.

    • Jacqueline Lim
    • , Christopher Tennant
    • , Arto Mannermaa
    • , Veli-Matti Kosma
    • , Vesa Kataja
    •  & Jaana Hartikainen
  119. Breast Cancer Laboratory, Walter and Eliza Hall Institute, PO Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.

    • Geoff Lindeman
    • , Arto Mannermaa
    • , Veli-Matti Kosma
    •  & Jaana Hartikainen
  120. Medical Oncology and Clinical Haematology Unit, Western Hospital, Footscray, Victoria 3011, Australia.

    • Lara Lipton
    •  & Vesa Kataja
  121. WA Centre for Cancer, Edith Cowan University, Churchlands, Western Australia 6018, Australia.

    • Liz Lobb
  122. Department of Psychological Medicine, University of Sydney, New South Wales 2006, Australia.

    • Mariette Maclurcan
    •  & Melanie Price
  123. Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia.

    • Deborah Marsh
  124. Cancer Epidemiology Research Unit, NSW Cancer Council, 153 Dowling Street, Woolloomooloo, New South Wales 2011, Australia.

    • Margaret McCredie
  125. Department of Oncology, St Vincent’s Hospital, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.

    • Sue Anne McLachlan
  126. School of Public Health, Queensland University of Technology, Victoria Park, Kelvin Grove, Queensland 4059, Australia.

    • Beth Newman
  127. St Vincent’s Breast Clinic, PO Box 4751, Toowoomba, Queensland 4350, Australia.

    • Imelda O’Loughlin
    • , Graham Warren
    •  & Elizabeth Watson
  128. Radiation Oncology, Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Victoria 3002, Australia.

    • Lester Peters
  129. Genetic Services, Auckland Hospital, Private Bag 92024, Auckland 1142, New Zealand.

    • Jeanne Reeve
    •  & Ingrid Winship
  130. Cancer Genetics Laboratory, University of Otago, PO Box 56, Dunedin 9054, New Zealand.

    • Tony Reeve
  131. Department of Cytogenetics and Molecular Genetics, Women and Children’s Hospital, Adelaide, South Australia 5006, Australia.

    • Robert Richards
  132. Hancock Family Breast Cancer Foundation, PO Locked Bag 2, West Perth, Western Australia 6005, Australia.

    • Gina Rinehart
  133. Oncology Service, Christchurch Hospital, Private Bag 4710, Christchurch 8140, New Zealand.

    • Bridget Robinson
  134. Molecular Pathology Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia 5000, Australia.

    • Barney Rudzki
  135. Section of Cytology, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia.

    • Elizabeth Salisbury
  136. School of Surgery and Pathology, QE11 Medical Centre, M block 2nd Floor, Nedlands, Western Australia 6907, Australia.

    • Christobel Saunders
  137. South View Clinic, Suite 13, Level 3 South Street, Kogarah, New South Wales 2217, Australia.

    • Elizabeth Scott
  138. Department of Obstetrics and Gynaecology, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

    • Andrew Shelling
  139. Department of Radiology, Royal Perth Hospital, Box X2213, Perth 6011, Western Australia, Australia.

    • Donna Taylor
  140. Murdoch Institute, Royal Children’s Hospital, Parkville, Victoria 3050, Australia.

    • Deon Venter
  141. Molecular Genetics of Cancer Division, Walter & Eliza Hall Medical Research Institute, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia.

    • Jane Visvader
  142. Department of Medical Oncology, St Vincents Hospital, Darlinghurst, New South Wales 2010, Australia.

    • Robin Ward
  143. Cabrini Hospital, 183 Wattletree Road, Malvern, Victoria 3144, Australia.

    • Bev Warner
  144. Family Cancer Clinic, St Vincent’s Hospital, Darlinghurst, New South Wales 2010, Australia.

    • Rachael Williams
  145. Medical Psychology Research Unit, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia.

    • Judy Wilson
  146. Cancer Genomics & Biochemistry Laboratory, Peter MacCallum Cancer Centre, St Andrew’s Place, East Melbourne, Victoria 3002, Australia.

    • David Bowtell
  147. Obstetrics & Gynaecology, Westmead Hospital, University of Sydney, New South Wales 2006, Australia.

    • Anna deFazio
  148. Lists of consortia participants and affiliations appear after author affiliations.

Consortia

  1. The SEARCH collaborators

  2. kConFab

  3. AOCS Management Group

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Competing interests

Reprints and permissions information is available at www.nature.com/reprints. The authors declare no competing financial interests.

Corresponding author

Correspondence to Douglas F. Easton.

Supplementary information

PDF files

  1. 1.

    Supplementary Information 1

    This file contains Supplementary Figures S1-S3, Supplementary Tables 1-11 and additional references.

  2. 2.

    Supplementary Information 3

    This file contains additional acknowledgements.

Excel files

  1. 1.

    Supplementary Information 2

    This file contains Supplementary Data

About this article

Publication history

Received

Revised

Accepted

Published

DOI

https://doi.org/10.1038/nature05887

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