Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cancer biology

Gone but not forgotten

The p53 tumour-suppressor protein is a cell's principal guardian against cancer. Most cancers eliminate p53 — but it seems that its pathway remains intact, so resurrecting it might provide a cancer therapy.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Approaches to reactivating the p53 pathway.


  1. This article and the Nature papers concerned3,4 were published online on 24 January 2007.


  1. Felsher, D. W. & Bishop, J. M. Mol. Cell 4, 199–207 (1999).

    Article  CAS  Google Scholar 

  2. Chin, L. et al. Nature 400, 468–472 (1999).

    Article  ADS  CAS  Google Scholar 

  3. Ventura, A. et al. Nature 445, 661–665 (2007).

    Article  CAS  Google Scholar 

  4. Xue, W. et al. Nature 445, 656–660 (2007).

    Article  CAS  Google Scholar 

  5. Martins, C. P., Brown-Swigart, L. & Evan, G. I. Cell 127, 1323–1334 (2006).

    Article  CAS  Google Scholar 

  6. Kola, I. & Landis, J. Nature Rev. Drug Discov. 3, 711–715 (2004).

    Article  CAS  Google Scholar 

  7. Narita, M. & Lowe, S. W. Nature Med. 11, 920–922 (2005).

    Article  CAS  Google Scholar 

  8. Dimri, G. P. et al. Proc. Natl Acad. Sci. USA 92, 9363–9367 (1995).

    Article  ADS  CAS  Google Scholar 

  9. Herbig, U., Ferreira, M., Condel, L., Carey, D. & Sedivy, J. M. Science 311, 1257 (2006).

    Article  CAS  Google Scholar 

  10. Michaloglou, C. et al. Nature 436, 720–724 (2005).

    Article  ADS  CAS  Google Scholar 

  11. Courtois-Cox, S. et al. Cancer Cell 10, 459–472 (2006).

    Article  CAS  Google Scholar 

  12. Vassilev, L. T. et al. Science 303, 844–848 (2004).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sharpless, N., DePinho, R. Gone but not forgotten. Nature 445, 606–607 (2007).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing