Hepatitis C and liver transplantation


Liver transplantation is a life-saving therapy to correct liver failure, portal hypertension and hepatocellular carcinoma arising from hepatitis C infection. But despite the successful use of living donors and improvements in immunosuppression and antiviral therapy, organ demand continues to outstrip supply and recurrent hepatitis C with accelerated progression to cirrhosis of the graft is a frequent cause of graft loss and the need for retransplantation. Appropriate selection of candidates and timing of transplantation, coupled with better pre- and post-transplant antiviral therapy, are needed to improve outcomes.

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Figure 1: The mathematical model MELD can predict the survival of candidates waiting for a liver transplant.
Figure 2: Survival benefit of pursuing live donor liver transplantation (LDLT).
Figure 3: Number of live donor liver transplants in the United States.
Figure 4: Management of hepatitis C and liver transplantation.


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Brown, R. Hepatitis C and liver transplantation. Nature 436, 973–978 (2005). https://doi.org/10.1038/nature04083

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