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CRISPR fixes disease gene in viable human embryos

Nature volume 548, pages 13–14 (2017)Cite this article

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A Correction to this article was published on 05 October 2017

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Gene-editing experiment pushes scientific and ethical boundaries.

An international team of researchers has used CRISPR–Cas9 gene editing — a technique that allows scientists to make precise changes to genomes with relative ease — to correct a disease-causing mutation in dozens of viable human embryos. The study represents a significant improvement in efficiency and accuracy over previous efforts.

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Change history

  • 03 October 2017

    An earlier version of this story incorrectly stated that all 42 embryos with normal copies of MYBPC3 were successfully edited.

References

  1. Ma, H. et al. Nature http://dx.doi.org/10.1038/nature23305 (2017).

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  1. Heidi Ledford
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Related links in Nature Research

UK bioethicists eye designer babies and CRISPR cows 2016-Sep-30

Second Chinese team reports gene editing in human embryos 2016-Apr-08

Should you edit your children’s genes? 2016-Feb-23

UK scientists gain licence to edit genes in human embryos 2016-Feb-01

Enzyme tweak boosts precision of CRISPR genome edits 2016-Jan-06

Global summit reveals divergent views on human gene editing 2015-Dec-08

Nature special: CRISPR

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National Academies of Science, Engineering, and Medicine: Human Gene-Editing Initiative

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Ledford, H. CRISPR fixes disease gene in viable human embryos. Nature 548, 13–14 (2017). https://doi.org/10.1038/nature.2017.22382

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