Ex vivo patch clamp electrophysiology (holding voltage: −70 mV) of endogenous pyramidal neurons demonstrated significantly higher sIPSC amplitudes and shorter inter-event intervals compared to dead cell controls. When TTX was added and mIPSCs were analyzed, the difference in amplitudes between groups was eliminated, but inter-event intervals remained shorter compared to dead cell controls. Example traces are depicted and a representative pyramidal cell, labeled with neurobiotin, is shown. Scale bar is 50 μm. n=13–34 cells from 2–3 rats/group. For more information on this topic, please refer to the article by Donegan et al. on pages 1492–1501.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Donegan, J., Tyson, J., Branch, S. et al. Stem cell-derived interneuron transplants functionally integrate within the existing circuitry. Mol Psychiatry 22, 1369 (2017). https://doi.org/10.1038/mp.2017.198
Published:
Issue Date:
DOI: https://doi.org/10.1038/mp.2017.198