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Stem cell-derived interneuron transplants functionally integrate within the existing circuitry

Molecular Psychiatry volume 22, page 1369 (2017)Cite this article

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Ex vivo patch clamp electrophysiology (holding voltage: −70 mV) of endogenous pyramidal neurons demonstrated significantly higher sIPSC amplitudes and shorter inter-event intervals compared to dead cell controls. When TTX was added and mIPSCs were analyzed, the difference in amplitudes between groups was eliminated, but inter-event intervals remained shorter compared to dead cell controls. Example traces are depicted and a representative pyramidal cell, labeled with neurobiotin, is shown. Scale bar is 50 μm. n=13–34 cells from 2–3 rats/group. For more information on this topic, please refer to the article by Donegan et al. on pages 1492–1501.

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Authors and Affiliations

  1. Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA

    J J Donegan & D J Lodge

  2. Department of Psychiatry, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    J A Tyson & S A Anderson

  3. Department of Physiology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA

    S Y Branch & M J Beckstead

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  1. J J Donegan
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  2. J A Tyson
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  3. S Y Branch
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  4. M J Beckstead
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  5. S A Anderson
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  6. D J Lodge
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Donegan, J., Tyson, J., Branch, S. et al. Stem cell-derived interneuron transplants functionally integrate within the existing circuitry. Mol Psychiatry 22, 1369 (2017). https://doi.org/10.1038/mp.2017.198

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