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Molecular psychiatry of zebrafish

Molecular Psychiatry volume 20, pages 2–17 (2015)Cite this article

Abstract

Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling central nervous system (CNS) disorders. In particular, we outline recent genetic and technological developments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern molecular psychiatry research.

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Acknowledgements

The authors’ research has been supported by grants from the National Institutes of Health (NIAAA AA015325-01A2 to RG, NIDA DA030900-02 to AVK and NINDS NS077295-01 to JFPU), the EU FP7 Framework Program (Grant 602805 to WHJN), as well as the National Center for the Replacement, Reduction and Refinement of Animals in Research (NC3Rs, UK, G1000053 to CHB) and the Medical Research Council (MRC, UK to CHB). CHB is a Royal Society (UK) Industrial Research Fellow. The study was coordinated and facilitated by the International Zebrafish Neuroscience Research Consortium (ZNRC). AVK is the Director of ZENEREI Institute and Chair of ZNRC.

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Author notes

  1. A M Stewart, J F P Ullmann and W H J Norton: These authors contributed equally to this work.

Authors and Affiliations

  1. ZENEREI Institute, Slidell, LA, USA

    A M Stewart & A V Kalueff

  2. International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA

    A M Stewart, J F P Ullmann, W H J Norton & A V Kalueff

  3. Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia

    J F P Ullmann

  4. Department of Biology, College of Medicine, Biological Sciences and Psychiatry, University of Leicester, Leicester, UK

    W H J Norton

  5. School of Biological and Chemical Sciences, Queen Mary University of London, London, UK

    M O Parker & C H Brennan

  6. Department of Psychology, University of Toronto at Mississauga, Mississauga, Ontario, Canada

    R Gerlai

  7. Research Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong, China

    A V Kalueff

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  1. A M Stewart
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Stewart, A., Ullmann, J., Norton, W. et al. Molecular psychiatry of zebrafish. Mol Psychiatry 20, 2–17 (2015). https://doi.org/10.1038/mp.2014.128

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  • DOI: https://doi.org/10.1038/mp.2014.128

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