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Evaluating risk loci for schizophrenia distilled from genome-wide association studies in Han Chinese from central China

Molecular Psychiatry volume 18, pages 638–639 (2013)Cite this article

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Schizophrenia is a complex psychiatric disorder with a high heritability. The exact mechanism and risk factors for this disease have not been sufficiently resolved despite decades of extensive study.1 Recently, two genome-wide association studies (GWAS) in Han Chinese identified a total of nine single-nucleotide polymorphisms (SNPs) that reached genome-wide significance level,2, 3 but none of these risk loci was overlapped in the two studies. We genotyped these SNPs in Han Chinese from Hunan Province, China, and identified no association of any claimed SNP with schizophrenia.

A total of 976 unrelated schizophrenia patients and 1,043 matched healthy controls, all of Han Chinese, were recruited from Hunan Province in Central China. Patients with schizophrenia were diagnosed independently by two psychiatrists according to DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) criteria. The controls were clinically diagnosed as having no psychiatric disorders or other diseases. All participants or supervisors of patients signed informed consent and this study was approved by the institutional review boards of the Kunming Institute of Zoology and the Second Xiangya Hospital.

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Authors and Affiliations

  1. Institute of Mental Health, the Second Xiangya Hospital, Central South University, Hunan, China

    L Ma, J Tang, W Liu, D Wang & X Chen

  2. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China

    L Ma, D Wang, W Zhang, X-H Liu, W Gong & Y-G Yao

  3. Graduate School of the Chinese Academy of Sciences, Beijing, China

    L Ma, D Wang, W Zhang & X-H Liu

  4. School of Life Sciences, University of Science and Technology of China, Anhui, China

    W Gong

  5. These authors contributed equaly to this work,

    L Ma & J Tang

Authors
  1. L Ma
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  2. J Tang
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  3. D Wang
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  4. W Zhang
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  5. W Liu
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  6. D Wang
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  7. X-H Liu
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  8. W Gong
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  9. Y-G Yao
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  10. X Chen
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Corresponding authors

Correspondence to Y-G Yao or X Chen.

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Ma, L., Tang, J., Wang, D. et al. Evaluating risk loci for schizophrenia distilled from genome-wide association studies in Han Chinese from central China. Mol Psychiatry 18, 638–639 (2013). https://doi.org/10.1038/mp.2012.63

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