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Parent-of-origin allelic contributions to deiodinase-3 expression elicit localized hyperthyroid milieu in the hippocampus

Molecular Psychiatry volume 16, pages 786–787 (2011)Cite this article

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Thyroid hormone deficiency and excess have long been associated with mood- and anxiety-related disorders. Adjuvant treatment with high doses of thyroid hormone has been used effectively to treat mood disorders in the absence of peripheral thyroid disease,1, 2 suggesting that aberrant central, but not necessarily peripheral, thyroid hormone levels relate to the symptoms. Levels of the active thyroid hormone, 3,5,3′ triiodothyronine (T3), are maintained differentially across tissues by thyroid hormone transporters, and the three iodothyronine selenodeiodinases (type 1, 2, and 3) together allow the molecular actions of T3 to be locally specific.3 The adult brain contains high levels of Dio3, which serves a significant role as it is the sole inactivator of T3 and because it is subject to genetic imprinting.4, 5

Genetic imprinting (non-equivalent parental genetic contributions to gene expression) is prevalent in the brain and furthermore, imprinting patterns can differ across brain regions.6, 7 We hypothesized that the Dio3 gene is region specifically imprinted because thyroid homeostasis is maintained in individual brain regions, independently from the periphery and other regions.8 We tested this hypothesis by reciprocally mating Sprague–Dawley (S) and Brown Norway (B) rats, which harbor a single-nucleotide polymorphism in the Dio3 exon, to generate two hybrid rat strains. We then tracked allele-specific expression of Dio3 in the F1BS and F1SB hybrid offspring.

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, The Asher Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    L J Sittig, P K Shukla & E E Redei

  2. Department of Pediatrics, Children's Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

    L B K Herzing

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  1. L J Sittig
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  2. L B K Herzing
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  3. P K Shukla
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  4. E E Redei
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Correspondence to E E Redei.

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Sittig, L., Herzing, L., Shukla, P. et al. Parent-of-origin allelic contributions to deiodinase-3 expression elicit localized hyperthyroid milieu in the hippocampus. Mol Psychiatry 16, 786–787 (2011). https://doi.org/10.1038/mp.2011.19

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