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Missing link; urocortins in dorsal raphe

The missing link; the significance of urocortin 1/urocortin 2 in the modulation of the dorsal raphe serotoninergic system

Molecular Psychiatry volume 15, pages 340–341 (2010)Cite this article

An elegant study by Neufeld-Cohen et al.1 provides evidence that the interaction of urocortins with corticotrophin-releasing factor (CRF) receptor-type 2 (CRFR2) in the dorsal raphe serotoninergic system could have an important role in regulating homeostatic equilibrium under stress.

Compelling evidence suggests that the dysfunction of CRF, a critical mediator of the stress response, has a causal role in stress-associated psychiatric disorders.2, 3, 4 One classical mechanism by which CRF links stress and depression is through its regulation of the serotonin-containing dorsal raphe nucleus (DR).5

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References

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Authors and Affiliations

  1. Department of Cellular Animal Physiology, Donders Center for Brain, Cognition and Behavior, Radboud University Nijmegen, Toernooiveld 1, Nijmegen, 6525AJ, The Netherlands

    T Kozicz

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  1. T Kozicz
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Correspondence to T Kozicz.

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Kozicz, T. The missing link; the significance of urocortin 1/urocortin 2 in the modulation of the dorsal raphe serotoninergic system. Mol Psychiatry 15, 340–341 (2010). https://doi.org/10.1038/mp.2009.134

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