Focus on the immunology of tuberculosis
Mycobacterium tuberculosis infects nearly one-third of the world’s population and is a major killer. This issue of Mucosal Immunology, graciously guest-edited by Dr. Alan Sher, is focused on major new developments in our understanding of the immunology of tuberculosis, with the goal of stimulating thought on new mechanisms of prevention and treatment of this devastating disease.
Mucosal infections
Sharon Perry and colleagues discuss data indicating that distinct mucosal infections influence the acquisition and outcome of M. tuberculosis. See page 246
Innate cytokines
In this insightful review, Andrea Cooper and colleagues describe major innate cytokine pathways in the establishment and maintenance of M. tuberculosis. See page 252
Interleukin-10
Paul Redford and colleagues examine the central role of interleukin-10 in the fine balance of immunopathology and protection against M. tuberculosis. See page 261
Granulomatous inflammation
JoAnne Flynn and colleagues discuss the key role of the macrophage in M. tuberculosis granulomas. See page 271
Macrophage apoptosis
Samuel Behar and colleagues explain how M. tuberculosis can subvert macrophage apoptosis, an important innate defense mechanism. See page 279
T-cell control of tuberculosis
Kevin Urdahl and colleagues discuss the induction and control of T-cell responses against M. tuberculosis infection. See page 288
Leptin and E. histolytica
Xiaoti Guo and colleagues have identified an essential role for leptin signaling in resistance to Entamoeba histolytica infection. See page 294
PPAR-γ and macrophages
Raquel Hontecillas and colleagues show that peroxisome proliferator–activated receptor-γ regulates macrophage function and T-cell responses in experimental colitis. See page 304
Ndfip1 in Th2 inflammation
Hilda Ramon and colleagues indicate a role for the adaptor protein in intestinal inflammation. See page 314
Lymphocyte control of Nod2
Claudia Duerr and colleagues demonstrate that intestinal lymphocytes can degrade muramyl dipeptide and prevent its recognition by nucleotide-binding oligomerization domain 2. See page 325
Epithelial defense
Charles Wira and colleagues demonstrate that epithelial cell secretions from the upper female reproductive tract can inhibit the growth of Neisseria gonorrhoeae, Candida species, and HIV. See page 335
DCs in lung allergy
Alejandro Ortiz-Stern and colleagues show a essential role for langerin-positive dendritic cells in lipopolysaccharide-induced exacerbation of airway inflammation. See page 343
Muc2 mutations and IBD
Rajaraman Eri and colleagues demonstrate that missense mutations in Muc2 result in endoplasmic reticulum stress in goblet cells and spontaneous intestinal inflammation. See page 354
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In this Issue. Mucosal Immunol 4, 245 (2011). https://doi.org/10.1038/mi.2011.19
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DOI: https://doi.org/10.1038/mi.2011.19