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References
Mi JQ, Li JM, Shen ZX, Chen SJ, Chen Z . How to manage acute promyelocytic leukemia. Leukemia 2012; 26: 1743–1751.
Lo-Coco F, Avvisati G, Vignetti M, Thiede C, Orlando SM, Iacobelli S et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 2013; 369: 111–121.
Kra J, Shapira I, Grossbard ML . Extremely late extramedullary relapse of acute promyelocytic leukemia, case report and review of the literature. J Hematol 2012; 1: 108–111.
Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 2014; 506: 328–333.
Welch JS, Yuan W, Ley TJ . PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice. J Clin Invest 2011; 121: 1636–1645.
Acknowledgements
We thank Dr F Lo Coco (University Tor Vergata, Rome, Italy) for clinical advices. The study was supported by grants from the National Basic Research Program of China (Grant No. 973 Program 2010CB529202 and 2012CB911202), the Adolf H Lundin Charitable Foundation, Swedish Cancer Society, the Swedish Research Council, Cancer Society in Stockholm, and the regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet, the National Natural Science Foundation of China (81070224, 81071721, 81000868 and 81171536) and Program for New Century Excellent Talents in University (NCET-10-0555).
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Conception and design: X Zhang, Q Zhang, D Xu and M Björkholm; WGS and array-CGH and analysis: Q Zhang, AN Tran, B Yang and Z Gu; acquisition of data: X Zhang; Q Zhang, J Dahlström, Å Derolf, M Ghaderi, A Porwit, D Xu and M Björkholm; analysis and interpretation of data: X Zhang, Q Zhang, AN Tran, J Jia, D Xu and M Björkholm; writing, review and/or revision of the manuscript: X Zhang, Q Zhang, D Xu and M Björkholm.
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Zhang, X., Zhang, Q., Dahlström, J. et al. Genomic analysis of the clonal origin and evolution of acute promyelocytic leukemia in a unique patient with a very late (17 years) relapse. Leukemia 28, 1751–1754 (2014). https://doi.org/10.1038/leu.2014.113
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DOI: https://doi.org/10.1038/leu.2014.113