This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging
Stem Cell Reviews and Reports Open Access 22 February 2017
-
Endothelial progenitor cell levels in juvenile idiopathic arthritis patients; effects of anti-inflammatory therapies
Pediatric Rheumatology Open Access 19 February 2015
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Shin DM, Kucia M, Ratajczak MZ . Nuclear and chromatin reorganization during cell senescence and aging—a mini-review. Gerontology 2010; 57: 76–84.
Flores I, Blasco MA . The role of telomeres and telomerase in stem cell aging. FEBS Lett 2010; 584: 3826–3830.
Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ . Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 2000; 141: 2608–2613.
Coschigano KT, Holland AN, Riders ME, List EO, Flyvbjerg A, Kopchick JJ et al. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 2003; 144: 3799–3810.
Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO . Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell 2008; 7: 681–687.
Bartke A . Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology 2003; 78: 210–216.
Ikeno Y, Hubbard GB, Lee S, Cortez LA, Lew CM, Webb CR et al. Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci 2009; 64: 522–529.
Russell SJ, Kahn CR . Endocrine regulation of ageing. Nat Rev Mol Cell Biol 2007; 8: 681–691.
Ratajczak J, Zhang Q, Pertusini E, Wojczyk BS, Wasik MA, Ratajczak MZ . The role of insulin (INS) and insulin-like growth factor-I (IGF-I) in regulating human erythropoiesis. Studies in vitro under serum-free conditions—comparison to other cytokines and growth factors. Leukemia 1998; 12: 371–381.
Reik W, Walter J . Genomic imprinting: parental influence on the genome. Nat Rev Genet 2001; 2: 21–32.
Kucia M, Reca R, Campbell FR, Zuba-Surma E, Majka M, Ratajczak J et al. A population of very small embryonic-like (VSEL) CXCR4+SSEA-1+Oct-4+ stem cells identified in adult bone marrow. Leukemia 2006; 20: 857–869.
Ratajczak J, Wysoczynski M, Zuba-Surma E, Wan W, Kucia M, Yoder MC et al. Adult murine bone marrow-derived very small embryoniclike stem cells (VSELs) differentiate into the hematopoietic lineage after co-culture over op9 stromal cells. Exp Hematol 2011; 39: 225–237.
Shin DM, Zuba-Surma EK, Wu W, Ratajczak J, Wysoczynski M, Ratajczak MZ et al. Novel epigenetic mechanisms that control pluripotency and quiescence of adult bone marrow-derived Oct4+ very small embryonic-like stem cells. Leukemia 2009; 23: 2042–2051.
Ratajczak MZ, Shin DM, Ratajczak J, Kucia M, Bartke A . A novel insight into aging: are there pluripotent very small embryonic-like stem cells (VSELs) in adult tissues overtime depleted in an Igf-1-dependent manner? Aging 2010; 2: 875–883.
Ratajczak J, Shin DM, Wan W, Liu R, Masternak MM, Piotrowska K, et al. Higher number of stem cells in the bone marrow of circulating low Igf-1 level Laron dwarf mice-novel view on Igf-1, stem cells and aging. Leukemia 2011; 25: 729–733.
Westbrook R, Bonkowski MS, Strader AD, Bartke A . Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice. J Gerontol A Biol Sci Med Sci 2009; 64: 443–451.
Feinberg AP . Phenotypic plasticity and the epigenetics of human disease. Nature 2007; 447: 433–440.
Acknowledgements
This work was supported by NIH R01 DK074720, KBN grant (N N401 024536), EU structural funds, Innovative Economy Operational Program POIG.01.01.01-00-109/09-01 and the Henry M and Stella M Hoenig Endowment to MZR, by NIH P20RR018733 from the National Center for Research Resources to MK, NIH P01 AG031736 to AB and NIH AG032290 to MMM.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Kucia, M., Shin, DM., Liu, R. et al. Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging. Leukemia 25, 1370–1374 (2011). https://doi.org/10.1038/leu.2011.98
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2011.98
This article is cited by
-
Identification of Human Very Small Embryonic like Stem Cells (VSELS) in Human Heart Tissue Among Young and Old Individuals
Stem Cell Reviews and Reports (2020)
-
Rates of erythropoiesis in mammals and their relationship with lifespan and hematopoietic stem cells aging
Biogerontology (2019)
-
Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging
Stem Cell Reviews and Reports (2017)
-
Endothelial progenitor cell levels in juvenile idiopathic arthritis patients; effects of anti-inflammatory therapies
Pediatric Rheumatology (2015)