Abstract
Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein–protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of ‘differentiation therapy’ to restore normal cellular differentiation of leukemic cells is discussed.
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Acknowledgements
We apologize to the many authors whose work we could not cite owing to space constraints. This work was supported by the grant from Internal Grant Agency of Ministry of Health of the Czech Republic (NR9021-4/2006). Work in P Laslo's laboratory is funded by the Yorkshire Cancer Research and the Wellcome Trust.
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Burda, P., Laslo, P. & Stopka, T. The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis. Leukemia 24, 1249–1257 (2010). https://doi.org/10.1038/leu.2010.104
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DOI: https://doi.org/10.1038/leu.2010.104
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