Abstract
Researchers have extensively used animal models to study diabetes mellitus. In this study, the authors determined the susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus. For 8 months, the researchers fed Nongda control minipigs (n = 4) a normal diet and fed Bama, Wuzhishan and Nongda minipigs (n = 6 per group) a high-sucrose, high-fat diet. They measured the minipigs' body weights, fasting serum glucose concentrations and insulin concentrations each month. Every 2 months, they measured serum triglyceride, cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and carried out intravenous glucose tolerance tests (IVGTTs). The Bama and Wuzhishan minipigs were relatively susceptible to diabetes induced by the high-sucrose, high-fat diet, though susceptibility differed among individual animals in the same strain. On the other hand, Nongda minipigs were relatively resistant to diet-induced diabetes. These results provide a foundation for diabetes-related genetic analyses in minipigs with high and low susceptibility to diet-induced type 2 diabetes.
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Chen, H., Liu, Yq., Li, Ch. et al. The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus. Lab Anim 38, 355–363 (2009). https://doi.org/10.1038/laban1109-355
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DOI: https://doi.org/10.1038/laban1109-355
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