Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Meeting Summary
  • Published:

Report of the 2005 RSPCA/UFAW Rodent Welfare Group meeting

An Erratum to this article was published on 01 November 2006

Abstract

The RSPCA/UFAW Rodent Welfare Group holds a one-day meeting every autumn for its members to discuss current welfare research and exchange views on rodent welfare issues. A key aim of the group is to encourage people to think about the whole lifetime experience of laboratory rodents, ensuring that every potential impact on their well-being has been reviewed and refined. The 2005 meeting focused on the refinement of techniques used in the creation of GM rodents, especially genotyping and vasectomy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Burrowing behavior can be assessed by providing mice with tubes filled with food pellets.
Figure 2: PCR-based genotyping of transgenic mice using DNA extracted from ear tissue yields comparable results to assays using tail tip tissue.
Figure 3: The scrotal approach to vasectomy is an alternative to the commonly used, and more invasive, abdominal approach.

References

  1. Dantzer, R. et al. Mechanisms of the behavioural effects of cytokines. Adv. Exp. Med. Biol. 461, 83–105 (1999).

    Article  CAS  Google Scholar 

  2. Dantzer, R. et al. Molecular basis of sickness behavior. Ann. N.Y. Acad. Sci. 856, 132–138 (1998).

    Article  CAS  Google Scholar 

  3. Felton, L.M. et al. MCP-1 and murine prion disease: Separation of early behavioural dysfunction from overt clinical disease. Neurobiol. Dis. 20(2), 283–295 (2005).

    Article  Google Scholar 

  4. Dudek, B.C., Adams, N., Boice, R. & Abbott, M.E. Genetic influences on digging behaviors in mice (Mus musculus) in laboratory and seminatural settings. J. Comp. Psychol. 97(3), 249–259 (1983).

    Article  Google Scholar 

  5. Cunningham, C. et al. Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease. Eur. J. Neurosci. 17(10), 2147–2155 (2003).

    Article  Google Scholar 

  6. Cunningham, C. et al. Neuropathologically distinct prion strains give rise to similar temporal profiles of behavioral deficits. Neurobiol. Dis. 18(2), 258–269 (2005).

    Article  Google Scholar 

  7. Xu, X.J. et al. Systemic mexiletine relieves chronic allodynialike symptoms in rats with ischemic spinal cord injury. Anesth. Analg. 74(5), 649–652 (1992).

    Google Scholar 

  8. Lu, Y. & Westlund, K.N. Gabapentin attenuates nociceptive behaviors in an acute arthritis model in rats. J. Pharmacol. Exp. Ther. 290(1), 214–219 (1999).

    Google Scholar 

  9. Narsinghani, U. & Anand, K.J. Developmental neurobiology of pain in neonatal rats. Lab Anim. (NY) 29(9), 27–39 (2000).

    Google Scholar 

  10. VAAWF/FRAMA/RSPCA/UFAW Joint Working Group on Refinement. Refinement and reduction in production of genetically modified mice. Lab. Anim. 37(Suppl 1), 1–49 (2003)

  11. Council of Europe. Council Directive of 24 November 1986 on the Approximation of Laws, Regulations and Administrative Provisions of the Member States regarding the Protection of Animals used for Experimental and Other Scientific Purposes (Official Journal of the European Communities L358, Luxembourg, 1986).

Download references

Acknowledgements

The Group thanks the speakers and everyone who attended and participated in the meeting. Thanks also to Joanne Wright for her administrative skills.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Penny Hawkins.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hawkins, P., Felton, L., van Loo, P. et al. Report of the 2005 RSPCA/UFAW Rodent Welfare Group meeting. Lab Anim 35, 29–38 (2006). https://doi.org/10.1038/laban1006-29

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/laban1006-29

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing