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Diagnosis: Urolithiasis

Lab Animal volume 32, pages 24–25 (2003)Cite this article

Both rats had urinary calculi in their urinary tracts. Rat A had calculi in the urinary bladder, while Rat B had calculi in the urinary bladder and kidneys. We sent out one stone from each rat for quantitative chemical analysis. Both stones were similar, and were composed of magnesium ammonium phosphate and calcium phosphate.

Histopathologic examination of the kidneys from Rat A revealed severe diffuse mixed lymphoplasmacytic and suppurative interstitial nephritis, suppurative pyelonephritis, glomerulosclerosis, the presence of cellular and eosinophilic casts in renal tubules, and nephrocalcinosis. The ureters had a diffuse mononuclear ureteritis and the urinary bladder showed a diffuse suppurative and mononuclear cystitis with mineralized calculi in the lumen.

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Authors and Affiliations

  1. Bingel is in the Department of Comparative Medicine, Medical University of South Carolina, 114 Doughty St., Charleston, SC 29425.,

    Sarah A. Bingel VMD, PhD

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  1. Sarah A. Bingel VMD, PhD
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Correspondence to Sarah A. Bingel VMD, PhD.

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Bingel, S. Diagnosis: Urolithiasis. Lab Anim 32, 24–25 (2003). https://doi.org/10.1038/laban0903-24

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