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Variation in exocrine pancreatic secretion in rats due to different commercial diets

Lab Animal volume 35, pages 41–49 (2006)Cite this article

Abstract

The diet fed to laboratory animals is one of many variables that can confound research results. The authors investigated the effect of the composition of commercial standard rodent diets on exocrine pancreatic function in rats. They compared two widely used commercial animal diets and found that diet composition greatly influences pancreatic secretion. Their results indicate that commercial diets should conform to the recommended composition requirements to avoid alterations in physiological functions that would eventually affect the results of biomedical research and that investigators should be keenly aware of the composition of the diets being fed to their animals.

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Figure 1: (a) Body weight in grams of rats eating commercial diets A (▪) and B (□).
Figure 2: (a) Comparison of basal pancreatic flow (μl/min/100 g BW) in rats eating diet A or diet B.
Figure 3: (a) CCK-stimulated pancreatic flow (μl/min/100 g BW) in rats receiving diet A (▪) or diet B (░).
Figure 4: (a) Secretin-evoked pancreatic flow (μl/min/100 g BW) in rats receiving diet A (▪) or diet B (░).

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Acknowledgements

Financial support for this work came from grants from Universidad de Buenos Aires (UBACYT B079 and UBACYT B903). The authors thank Dr. Anabel Pallaro for her kind collaboration and contribution to the discussion of this work.

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Authors and Affiliations

  1. Cátedras de Fisiopatologíaa, Universidad de Buenos Aires, Junin 956-Piso 7, Buenos Aires, 1113, Argentina

    María Eugenia Sabbatini, Mariana Rios &  Liliana G. Bianciotti

  2. Bromatología y, Universidad de Buenos Aires, Junin 956-Piso 7, Buenos Aires, 1113, Argentina

    Néstor Pellegrino

  3. Fisiología (IQUIMEFA-CONICET), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956-Piso 7, Buenos Aires, 1113, Argentina

    Marcelo S. Vatta

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  1. María Eugenia Sabbatini
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Correspondence to Marcelo S. Vatta.

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Sabbatini, M., Pellegrino, N., Rios, M. et al. Variation in exocrine pancreatic secretion in rats due to different commercial diets. Lab Anim 35, 41–49 (2006). https://doi.org/10.1038/laban0606-41

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