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Effects of Helicobacter infection on developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Holtzman rats

Lab Animal volume 37, pages 171–175 (2008)Cite this article

Abstract

To obtain accurate results from experiments in animal models, all potential confounding variables must be identified and controlled. The authors examined the effects of Helicobacter infection on developmental toxicity resulting from exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent and ubiquitous environmental contaminant. They administered different doses of TCDD to timed pregnant Helicobacter-positive and Helicobacter-negative Holtzman rats and evaluated fetal and neonatal viability. They also assessed hepatic cytochrome P450 induction and activity of the gene Cyp1a1, which are classic indicators of TCDD exposure. All rats were affected by TCDD, and Helicobacter infection seemed to have little influence on rats' susceptibility to the compound.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, 14214, NY

    Kevin M. Kransler,  Barbara P. McGarrigle &  James R. Olson

  2. Harlan Sprague Dawley, Inc., P.O. Box 29176, Indianapolis, 46229, IN

    Robert J. Russell

Authors
  1. Kevin M. Kransler
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  2. Barbara P. McGarrigle
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  3. Robert J. Russell
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  4. James R. Olson
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Corresponding author

Correspondence to James R. Olson.

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Competing interests

The authors declare competing financial interests. At the time of the study, R.J.R. was employed by Harlan Sprague Dawley, Inc., which provided the rats as a gift.

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Kransler, K., McGarrigle, B., Russell, R. et al. Effects of Helicobacter infection on developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Holtzman rats. Lab Anim 37, 171–175 (2008). https://doi.org/10.1038/laban0408-171

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