Abstract
Since no standard method for reproducibly irradiating local tumors of laboratory rodents exists, the authors designed a device to accurately irradiate rodent tumors. Laboratory personnel can easily assemble this inexpensive device. The new device delivers highly focused treatment and avoids the need for anesthesia and sedation. It represents an improvement over former improvised procedures done at the authors' institutions, because it allows for more accurate irradiation of rodent tumors. The authors used the device to irradiate single tumors on the left hind legs of 60 mice and 10 rats with a dosage of 7 gray (Gy) ionizing radiation. At time of irradiation, the clinical condition of the animals was very poor, but all animals survived the treatment.
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Acknowledgements
We wish to thank Mrs. Ute Haner (University of Heidelberg) for skilled technical assistance, Prof. Marc Bischof (University of Heidelberg) for giving the us access to the X-ray machine, Prof. Jennifer Reed (DKFZ Heidelberg) for reviewing the manuscript for proper English, Jutta Davidson (CRL Sulzfeld) for conducting a literature search and Dr. Oliver Schramm (University of Heidelberg) for providing physical radiation field characteristics.
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Huebner, G., Weber, K., Hartung, G. et al. Device for the local radiation of tumor-bearing laboratory rodents. Lab Anim 39, 55–58 (2010). https://doi.org/10.1038/laban0210-55
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DOI: https://doi.org/10.1038/laban0210-55
