Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Resource
  • Published:

Gross and histological description of the epidermal membrane found on normal neonatal piglets

Abstract

The structure and composition of fetal and placental tissues vary among different species of placental mammals. Some mammals, including camelids and pigs, possess an epidermal membrane during the fetal stage, called the epithelion, that is absent from other domestic mammals. Because neonatal piglets are a common animal model for many research techniques, it is important that researchers correctly identify this tissue and recognize its lack of pathological consequence when working with fetal and neonatal piglets. Here, the authors describe gross and histological examinations of the epithelion, comparing this tissue with other extra-fetal tissues and coatings.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3: Photomicrograph of the piglet epithelion, fixed in formalin, stained with hematoxylin and eosin, embedded in paraffin wax and sectioned at 5 μm.
Figure 4: Photomicrograph of the piglet amnion, fixed in formalin, stained with hematoxylin and eosin, embedded in paraffin wax and sectioned at 5 μm.

Similar content being viewed by others

References

  1. King, G.J. Comparative placentation in ungulates. J. Exp. Zool. 31, 588–602 (1982).

    Google Scholar 

  2. Friess, A.E., Sinowatz, F., Skolek-Winnisch, R. & Trautner, W. The placenta of the pig. I. Finestructural changes of the placental barrier during pregnancy. Anat. Embryol. 158, 179–191 (1980).

    Article  CAS  Google Scholar 

  3. Fowler, M.E. Medicine and Surgery of Camelids. 3rd edn. (Wiley-Blackwell, Hoboken, NJ, 2010).

    Book  Google Scholar 

  4. Musa, B.E. A new epidermal membrane associated with the foetus of the camel (Camelus dromedarius). Zb. Vet. Med. C Anat. Histol. Embryol. 6, 355–358 (1977).

    Article  CAS  Google Scholar 

  5. Morton, W.R.M. Observations on the full term foetal membranes of the three members of the Camelidae (Camelus dromedaries L., Camelus bactrianus L., and Lama glama L.). J. Anat. 95, 200–209 (1961).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Schmied, J., Rupa, P., Garvie, S. & Wilkie, B. Immune response phenotype of allergic versus clinically tolerant pigs in a neonatal swine model of allergy. Vet. Immunol. Immunop. 154, 17–24 (2013).

    Article  CAS  Google Scholar 

  7. Luo, X. et al. Effects of microporous porcine acellular dermal matrix combined with bone marrow mesenchymal cells of rats on regeneration of cutaneous apendages cells in nude mice. Zhongua Shao Shang Za Zhi 6, 541–547 (2013).

    Google Scholar 

  8. Bistoni, G. et al. Prolongation of skin allograft survival in rats by the transplantation of microencapsulated xenogeneic neonatal porcine Sertoli cells. Biomaterials. 33, 5333–5340 (2012).

    Article  CAS  Google Scholar 

  9. Brunton, J.A., Baldwin, M.P., Hanna, R.A. & Bertolo, R.F. Proline supplementation to paternal nutrition results in greater rates of protein synthesis in the muscle, skin, and small intestine in neonatal Yucatan miniature piglets. J. Nutr. 142, 1004–1008 (2012).

    Article  CAS  Google Scholar 

  10. Rauma, M. & Johanson, G. Comparison of the thermogravimetric analysis (TGA) and Franz cell methods to assess dermal diffusion of volatile chemicals. Toxicol. In Vitro 5, 919–926 (2009).

    Article  Google Scholar 

  11. Bressan, F.F. et al. Unearthing the roles of imprinted genes in the placenta. Placenta 30, 823–834 (2009).

    Article  CAS  Google Scholar 

  12. Sinclair, J.G. Anatomy of the Fetal Pig (Collegiate Press, Ames, Iowa, 1936).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jennifer M. Pearson.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pearson, J., Smith, M. & Schlafer, D. Gross and histological description of the epidermal membrane found on normal neonatal piglets. Lab Anim 44, 445–447 (2015). https://doi.org/10.1038/laban.890

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/laban.890

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing