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An ulcerating mass in the dorsum of a Swiss OF1 mouse

Lab Animal volume 43, pages 87–90 (2014)Cite this article

A 21-month-old, male Swiss OF1 mouse from the mouse breeding colony of the Experimental Animal Service of the University of Córdoba was housed in an individual cage at an ambient temperature of 21 ± 2 °C and 30–70% humidity on a 12-h:12-h light:dark cycle. The mouse had ad libitum access to a standard food pellet diet (Scientific Animal Food & Engineering, Villemoisson-sur-Orge, France) and drinking water. The animal had been maintained in accordance with the European Union Directive 2010/63/EU guidelines for the protection of animals used for scientific purposes.

We carried out necropsy of the mouse after euthanasia. At necropsy, we found an ulcerated lesion measuring 1.5 cm × 1.5 cm present in the dorsum. The cut surface was slightly bulging and white to grey in color, with hard and soft areas. All other organs and tissues appeared normal macroscopically.

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Figure 1
Figure 2: Microscopic view of the mass, stained with H&E.
Figure 3: Pleomorphic cells (arrowhead) and mitotic features (arrows).
Figure 4: Tumors infiltrated the underlying skeletal muscle (arrowhead) and small peripheral nerve (arrow).
Figure 5: Immunostained tumor cells.
Figure 6: Immunostained tumor cells.

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Acknowledgements

This work was supported by grants from the Junta de Andalucía (Andalusia, Spain) and Gobierno de España.

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Authors and Affiliations

  1. Department of Comparative Pathology, University of Córdoba, Córdoba, Spain

    Yolanda Millán Ruiz &  Juana Martín de las Mulas

  2. Department of Pharmacology, Toxicology and Legal and Forensic Medicine, University of Córdoba, Córdoba, Spain

    Ana Molina &  Rosario Moyano

  3. Department of Pathology, University of Córdoba, Córdoba, Spain

    Carlos Reymundo

Authors
  1. Yolanda Millán Ruiz
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  2. Ana Molina
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  3. Carlos Reymundo
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  4. Rosario Moyano
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  5. Juana Martín de las Mulas
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Correspondence to Yolanda Millán Ruiz.

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Ruiz, Y., Molina, A., Reymundo, C. et al. An ulcerating mass in the dorsum of a Swiss OF1 mouse. Lab Anim 43, 87–90 (2014). https://doi.org/10.1038/laban.287

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