Resource | Published:

Improved technique for induction and monitoring of audiogenic seizure in deer mice

Lab Animal 42, 166–169 (2013) | Download Citation

Subjects

Abstract

Epilepsy is a debilitating disease characterized by recurring seizures. Epilepsy can be studied using animal models, such as rodents prone to audiogenic seizure (AGS), which experience generalized seizures (loss of consciousness accompanied by rhythmic muscle spasms and rigid muscle stiffness) after intense sound stimulation. In 1933, a spontaneous mutation resulting in sensitivity to AGS was observed among laboratory stocks of deer mice (Peromyscus maniculatus artemisiae) at the University of Michigan. Since then, AGS-sensitive deer mice have been maintained as a separate stock, currently housed at the Peromyscus Genetic Stock Center. To further characterize AGS, the authors designed reliable and consistent equipment for inducing and monitoring AGS in deer mice.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

Rent or Buy

All prices are NET prices.

References

  1. 1.

    , & Recent advances in the genetics of epilepsy: insights from human and animal studies. Epilepsia 40, 1329–1352 (1999).

  2. 2.

    Single-gene models of epilepsy. Adv. Neurol. 79, 227–238 (1999).

  3. 3.

    & Developmental and genetic audiogenic seizure models: behavior and biological substrates. Neurosci. Biobehav. Rev. 24, 639–653 (2000).

  4. 4.

    et al. Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice. J. Neurosci. 22, 10088–10093 (2002).

  5. 5.

    & Genetic dissection of susceptibility to audiogenic seizures in inbred mice. Proc. Natl. Acad. Sci. USA 88, 5408–5412 (1991).

  6. 6.

    , , , & Genomic imprinting and audiogenic seizures in mice. Behav. Genet. 27, 465–475 (1997).

  7. 7.

    et al. A novel gene causing a mendelian audiogenic mouse epilepsy. Neuron 31, 537–544 (2001).

  8. 8.

    Inheritance of waltzing and of epilepsy in mice of the genus Peromyscus. J. Mammal. 16, 25–35 (1935).

  9. 9.

    The inheritance of epilepsy and of waltzing in Peromyscus. Contrib. Lab. Vert. Gen. Univ. Michigan No. 11 (1939).

  10. 10.

    Convulsive behavior in the rat. Psych. Bull. 44, 201–248 (1947).

  11. 11.

    Genetic differences in fatal audiogenic seizures between two inbred strains of house mice. J. Hered. 38, 2–6 (1947).

  12. 12.

    & New aspects of the behaviour of Peromyscus under audiogenic hyper-excitement. Behaviour 2, 96–105 (1949).

  13. 13.

    & Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science 236, 1567–1570 (1987).

  14. 14.

    Tests for independence of Waltzer and EP sonogenic convulsive from certain other genes in the deermouse (Peromyscus maniculatus). Contrib. Lab. Vert. Biol. Univ. Michigan No. 74 (1956).

  15. 15.

    Comparative Examples of Noise Levels (Industrial Noise Control, Inc., North Aurora, IL, 2000). .

  16. 16.

    , , & Deer mice as laboratory mice. ILAR J. 39, 322–330 (1998).

  17. 17.

    & Peromyscus—a fascinating laboratory animal model. TechTalk 11 (2006).

Download references

Author information

Affiliations

  1. Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, Columbia, SC.

    • Monika Veres
    • , Susan Payne
    • , Janet P. Crossland
    •  & Gabor Szalai

  2. Division of Science, Math & Engineering, University of South Carolina Sumter, Sumter, SC.

    • Pearl Fernandes

Authors

  1. Search for Monika Veres in:

  2. Search for Susan Payne in:

  3. Search for Pearl Fernandes in:

  4. Search for Janet P. Crossland in:

  5. Search for Gabor Szalai in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Gabor Szalai.

To obtain permission to re-use content from this article visit RightsLink.

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/laban.263