Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Considerations for aerobic exercise paradigms with rodent models

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: A rodent treadmill apparatus with removable dividers to accommodate six mice or three rats.
Figure 2: A voluntary wheel running apparatus for a single mouse in a cage.

References

  1. 1

    Mischel, N.A., Llewellyn-Smith, I.J. & Mueller, P.J. Physical (in)activity-dependent structural plasticity in bulbospinal catecholaminergic neurons of rat rostral ventrolateral medulla. J. Comp. Neurol. 522, 499–513 (2014).

    CAS  Article  Google Scholar 

  2. 2

    Mischel, N.A., Subramanian, M., Dombrowski, M.D., Llewellyn-Smith, I.J. & Mueller, P.J. (In)activity-related neuroplasticity in brainstem control of sympathetic outflow: unraveling underlying molecular, cellular, and anatomical mechanisms. Am. J. Physiol. Heart Circ. Physiol. 309, H235–H243 (2015).

    CAS  Article  Google Scholar 

  3. 3

    Subramanian, M., Holt, A.G. & Mueller, P.J. Physical activity correlates with glutamate receptor gene expression in spinally-projecting RVLM neurons: a laser capture microdissection study. Brain Res. 1585, 51–62 (2014).

    CAS  Article  Google Scholar 

  4. 4

    Gimenes, C. et al. Low intensity physical exercise attenuates cardiac remodeling and myocardial oxidative stress and dysfunction in diabetic rats. J. Diabetes Res. 2015, 457848 (2015).

    CAS  Article  Google Scholar 

  5. 5

    Glean, A.A. et al. Effects of nitrite infusion on skeletal muscle vascular control during exercise in rats with chronic heart failure. Am. J. Physiol. Heart Circ. Physiol. 309, H1354–H1360 (2015).

    CAS  Article  Google Scholar 

  6. 6

    Lee, I., Hüttemann, M., Kruger, A., Bollig-Fischer, A. & Malek, M.H. (-)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice. Front. Pharmacol. 6, 43 (2015).

    PubMed  PubMed Central  Google Scholar 

  7. 7

    Lee, I., Hüttemann, M., Liu, J., Grossman, L.I. & Malek, M.H. Deletion of heart-type cytochrome c oxidase subunit 7A1 impairs skeletal muscle angiogenesis and oxidative phosphorylation. J. Physiol. 590, 5231–5243 (2012).

    CAS  Article  Google Scholar 

  8. 8

    Hüttemann, M., Lee, I. & Malek, M.H. (-)-Epicatechin maintains endurance training adaptation in mice after 14 days of detraining. FASEB J. 26, 1413–1422 (2012).

    Article  Google Scholar 

  9. 9

    Olenich, S.A., Gutierrez-Reed, N., Audet, G.N. & Olfert, I.M. Temporal response of positive and negative regulators in response to acute and chronic exercise training in mice. J. Physiol. 591, 5157–5169 (2013).

    CAS  Article  Google Scholar 

  10. 10

    Allen, D.L. et al. Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse. J. Appl. Physiol. (1985) 90, 1900–1908 (2001).

    CAS  Article  Google Scholar 

  11. 11

    Lightfoot, J.T., Turner, M.J., Daves, M., Vordermark, A. & Kleeberger, S.R. Genetic influence on daily wheel running activity level. Physiol. Genomics 19, 270–276 (2004).

    CAS  Article  Google Scholar 

  12. 12

    Massett, M.P. & Berk, B.C. Strain-dependent differences in responses to exercise training in inbred and hybrid mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R1006–R1013 (2005).

    CAS  Article  Google Scholar 

  13. 13

    Barbato, J.C. et al. Spectrum of aerobic endurance running performance in eleven inbred strains of rats. J. Appl. Physiol. (1985) 85, 530–536 (1998).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Moh H. Malek.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Brossia-Root, L., Alworth, L. & Malek, M. Considerations for aerobic exercise paradigms with rodent models. Lab Anim 45, 213–215 (2016). https://doi.org/10.1038/laban.1023

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing