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Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh

Journal of Perinatology volume 36, pages 1039–1044 (2016)Cite this article

Subjects

Abstract

Objective:

To estimate the association between chorioamnionitis, maternal risk factors and birth outcomes.

Study Design:

A cross-sectional study of 600 pregnant women was conducted at a maternity center in Dhaka from January to October 2011. Outcomes included histologic, microbiologic and clinical chorioamnionitis. Log-binomial models assessed the association between risk factors and histologic chorioamnionitis (HC).

Results:

Of the 552 women with placental specimens, 70 (12.7%) were classified with HC: 46 (65.7%) with and 24 (34.3%) without fetal involvement. HC was associated with non-physician care (relative risk [RR] 2.04, 95% confidence interval [CI] 1.04 to 4.00), home slab or hanging latrine (RR 1.69, 95% CI 1.10 to 2.62), and lack of tetanus toxoid (RR 1.80, 95% CI 1.03 to 3.14). Women with fever (RR 2.30, 95% CI 1.18 to 4.50) or discolored amniotic fluid (RR 1.74, 95% CI 1.08 to 2.81) had a higher risk of HC. Microbiologic and clinical chorioamnionitis were unreliable HC measures.

Conclusion:

Prevalence of HC is high; many cases are not captured by clinical diagnosis or microbiologic cultures.

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Acknowledgements

We acknowledge financial support by the Thrasher Research Fund Early Career Award and a grant from the National Center for Research Resources (5KL2RR025006), a component of the National Institutes of Health (NIH) and the NIH Roadmap for Medical Research.

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Authors and Affiliations

  1. Division of Medicine Critical Care, Boston Children’s Hospital, Boston, MA, USA

    G J Chan & M Silverman

  2. Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    G J Chan

  3. Centre for Child and Adolescent Health, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

    M Zaman & A Mahmud

  4. Department of Pathology, Boston Children’s Hospital, Boston, MA, USA

    A Murillo-Chaves & T K Boyd

  5. Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    A H Baqui

Authors
  1. G J Chan
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  2. M Silverman
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  3. M Zaman
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  4. A Murillo-Chaves
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  5. A Mahmud
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  6. A H Baqui
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  7. T K Boyd
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Correspondence to G J Chan.

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Chan, G., Silverman, M., Zaman, M. et al. Prevalence and risk factors of chorioamnionitis in Dhaka, Bangladesh. J Perinatol 36, 1039–1044 (2016). https://doi.org/10.1038/jp.2016.150

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  • DOI: https://doi.org/10.1038/jp.2016.150

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