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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

Prolonged maternal postpartum fever and neonatal herpes infection

Abstract

Maternal postpartum fever that is suggestive of endometritis often triggers evaluation of the mother and newborn infant for bacterial infection. Two neonates whose mothers had persistent postpartum fever despite broad-spectrum antimicrobial therapy developed disseminated herpes simplex virus (HSV) infection. Obstetric and pediatric healthcare providers should be mindful of possible HSV infection if there is postpartum fever unresponsive to antibiotics, and both mother and neonate should be evaluated appropriately and treated promptly.

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References

  1. Remadi S, Finci V, Ismail A, Zacharie S, Vassilakos P . Herpetic endometritis after pregnancy. Pathol Res Pract 1995; 191 (1) 31–34.

    Article  CAS  Google Scholar 

  2. Hollier LM, Scott LL, Murphree SS, Wendel GD Jr . Postpartum endometritis caused by herpes simplex virus. Obstet Gynecol 1997; 89 (5 Pt 2): 836–838.

    Article  CAS  Google Scholar 

  3. Giraldo-Isaza MA, Jaspan D, Cohen AW . Postpartum endometritis caused by herpes and cytomegaloviruses. Obstet Gynecol 2011; 117 (2 Pt 2): 466–467.

    Article  Google Scholar 

  4. Hixson MJ, Collins JH . Postpartum herpes simplex endometritis. A case report. J Reprod Med 2001; 46 (9): 849–852.

    CAS  PubMed  Google Scholar 

  5. McGill AL, Bavaro MF, You WB . Postpartum herpes simplex virus endometritis and disseminated infection in both mother and neonate. Obstet Gynecol 2012; 120 (2 Pt 2): 471–473.

    Article  Google Scholar 

  6. Catlin EA, Warren HS, Shailam R, Lahoud-Rahme M, Lew M . Case records of the Massachusetts General Hospital. Case 19–2012. A premature newborn boy with respiratory distress. N Engl J Med 2012; 366 (25): 2409–2419.

    Article  CAS  Google Scholar 

  7. Shah SS, Aronson PL, Mohamad Z, Lorch SA . Delayed acyclovir therapy and death among neonates with herpes simplex virus infection. Pediatrics 2011; 128 (6): 1153–1160.

    Article  Google Scholar 

  8. Robb JA, Benirschke K, Barmeyer R . Intrauterine latent herpes simplex virus infection: I. Spontaneous abortion. Hum Pathol 1986; 17 (12): 1196–1209.

    Article  CAS  Google Scholar 

  9. Baker DA, Thomas J . The effect of prostaglandin E2 on the initial immune response to herpes simplex virus infection. Am J Obstet Gynecol 1985; 151 (5): 586–590.

    Article  CAS  Google Scholar 

  10. Cantey JB, Mejias A, Wallihan R, Doern C, Brock E, Salamon D et al. Use of blood polymerase chain reaction testing for diagnosis of herpes simplex virus infection. J Pediatr 2012; 161 (2): 357–361.

    Article  CAS  Google Scholar 

Download references

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Correspondence to M Anyebuno.

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Anyebuno, M., Lopez-Medina, E. & Sánchez, P. Prolonged maternal postpartum fever and neonatal herpes infection. J Perinatol 34, 716–717 (2014). https://doi.org/10.1038/jp.2014.82

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