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Leptin and leptin receptor polymorphisms and recurrent pregnancy loss

Journal of Perinatology volume 33, pages 589–592 (2013)Cite this article

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Abstract

Objective:

Leptin signaling is important in the establishment of pregnancy. We sought to determine if single nucleotide polymorphisms (SNPs) in the leptin and leptin receptor genes are associated with idiopathic recurrent pregnancy loss (RPL).

Study Design:

We conducted a case-control study with cases defined as women with idiopathic RPL and controls as parous women without pregnancy losses. A total of 99 cases and 108 controls were genotyped for the leptin (−2548 G/A) SNP and the leptin receptor A223G SNP. Genotype and allele frequencies were compared between cases and controls using χ2 test.

Result:

In this population, there was no significant difference in the genotype or allele frequencies for the leptin (−2548 G/A) or leptin receptor A223G SNPs between women with idiopathic RPL and controls.

Conclusion:

Although leptin signaling is critical to many aspects of reproduction, the maternal leptin and leptin receptor SNPs evaluated in this study are unlikely to have a clinically meaningful role in RPL.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Maternal-Fetal Medicine, University of Utah, Salt Lake City, UT, USA

    J R Chin, C C Heuser, A G Eller, D W Branch & R M Silver

  2. Maternal-Fetal Medicine, Intermountain Healthcare, Salt Lake City, UT, USA

    C C Heuser, A G Eller, D W Branch & R M Silver

  3. Taueret Laboratories, Salt Lake City, UT, USA

    L T Nelson

Authors
  1. J R Chin
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  2. C C Heuser
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  3. A G Eller
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  4. D W Branch
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Correspondence to J R Chin.

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The authors declare no conflict of interest.

Additional information

Presented in poster format at the 31st Annual Meeting of the Society for Maternal-Fetal Medicine, San Francisco, CA, USA, February 2011.

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Chin, J., Heuser, C., Eller, A. et al. Leptin and leptin receptor polymorphisms and recurrent pregnancy loss. J Perinatol 33, 589–592 (2013). https://doi.org/10.1038/jp.2013.25

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