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Pathogenesis of obstructive sleep apnoea in hypertensive patients: role of fluid retention and nocturnal rostral fluid shift

Journal of Human Hypertension volume 29, pages 342–350 (2015)Cite this article

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Abstract

Obstructive sleep apnoea (OSA) is highly prevalent in hypertensive patients, particularly those with drug resistance. Evidence from animal experiments, epidemiologic studies and clinical trials strongly suggest a causal link. Mechanistic studies argue for increased sympathetic neural activity and endothelial dysfunction. However, disturbances in fluid volume regulation and distribution may also be involved in the pathogenesis of these two conditions. Several studies have shown a high prevalence of OSA in fluid-retaining states including hypertension, a direct relationship between the severity of OSA and the volume of fluid displaced from the legs to the neck during sleep, and a decrease in upper airway cross-sectional area in response to graded lower body positive pressure. Treatments targeting fluid retention and redistribution, including diuretics, mineralocorticoid antagonists, exercise, and possibly renal denervation lower blood pressure and reduce the apnoea–hypopnoea index, a measure of OSA severity. From these observations, it has been postulated that during the daytime, excess fluid collects in the lower extremities due to gravity, and on lying down overnight is redistributed rostrally to the neck, where it may narrow the upper airway and increase its collapsibility, predisposing to OSA when pharyngeal dilator muscle activity decreases during sleep. This article discusses the associations between OSA and hypertension and reviews the evidence for fluid accumulation and its nocturnal rostral redistribution in the pathogenesis of OSA in hypertensive patients.

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Acknowledgements

This work was supported by grants-in-aid from the Heart and Stroke Foundation of Ontario and Canadian Institutes of Health Research. TDB is supported by the Cliff Nordal Chair in Sleep Apnea and Rehabilitation Research.

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Authors and Affiliations

  1. Sleep Research Laboratory, Toronto Rehabilitation Institute, Toronto, Ontario, Canada,

    L H White & T D Bradley

  2. Centre for Sleep Medicine and Circadian Biology of the University of Toronto, Toronto, Ontario, Canada,

    L H White & T D Bradley

  3. Department of Medicine of the University Health Network, Toronto General Hospital, Toronto, Ontario, Canada,

    T D Bradley

  4. Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada,

    T D Bradley & A G Logan

  5. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada,

    A G Logan

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  1. L H White
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  2. T D Bradley
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Correspondence to A G Logan.

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White, L., Bradley, T. & Logan, A. Pathogenesis of obstructive sleep apnoea in hypertensive patients: role of fluid retention and nocturnal rostral fluid shift. J Hum Hypertens 29, 342–350 (2015). https://doi.org/10.1038/jhh.2014.94

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  • DOI: https://doi.org/10.1038/jhh.2014.94

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