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Endothelial damage in white coat hypertension: role of lectin-like oxidized low-density lipoprotein-1

Journal of Human Hypertension volume 29, pages 92–98 (2015)Cite this article

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Abstract

The aims of this study included an examination of soluble lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (sLOX-1) levels in hypertensive (HT) patients. Another aim examined sLOX-1 associations with oxidized LDL (oxLDL), nitric oxide synthase (eNOS) and nitric oxide (NOx). A final aim was to compare these parameters between HT patients, white-coat hypertensive (WCH) patients and healthy controls. The three groups, HT, WCH and controls, were comprised of 35 patients each. sLOX-1 and oxLDL levels were significantly increased in WCH and HT patients compared with controls. The eNOS activation was significantly lower in HT than in the control group. sLOX-1 and oxLDL levels were significantly negatively correlated with eNOS levels in the WCH and HT groups. Carotid intima–media thickness (CIMT) measurements were significantly higher in the WCH and HT groups compared with controls. There was a significant positive correlation between CIMT and sLOX-1 and oxLDL; however, there was a negative correlation with eNOS in WCH. Regression analysis revealed that sLOX-1 was the variable that had a significant effect on blood pressure (P<0.001, odds ratio (95% confidence interval=23.273 (5.843–92.688)). A possible endothelial impairment may act as a cardiovascular risk factor in WCH. Necessary measures should be considered in terms of atherosclerosis risk with HT, especially in early identification of endothelial damage by looking at sLOX-1 levels. We believe sLOX-1 levels are strong biomarkers for determining early endothelial damage in HT, and especially in WCH patients.

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Acknowledgements

This work was supported by the Research Fund of Istanbul University (Project Number: 29559).

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Authors and Affiliations

  1. Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey

    S Yavuzer, H Yavuzer, M Cengiz, A L Yaldıran & Y Karter

  2. Department of Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey

    H Erman & H Uzun

  3. Department of Nephrology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey

    M R Altıparmak

  4. Department of Radiology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey

    B Korkmazer

  5. Central Research Laboratory, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey

    H Balci

  6. Department of Physiology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey

    G Simsek

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  1. S Yavuzer
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Correspondence to H Uzun.

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Yavuzer, S., Yavuzer, H., Cengiz, M. et al. Endothelial damage in white coat hypertension: role of lectin-like oxidized low-density lipoprotein-1. J Hum Hypertens 29, 92–98 (2015). https://doi.org/10.1038/jhh.2014.55

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