Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Serum omentin-1 levels in hypertensive patients

Journal of Human Hypertension volume 35, pages 290–295 (2021)Cite this article

Subjects

Abstract

Hypertension (HT) is a disease that can cause death due to multiple target organ damage and eventually related vascular system damage. High blood pressure is known increased inflammatory activity and to cause endothelial dysfunction has been showed in HT patients. Omentin-1 is a glucoprotein of the adiponectin family released from visceral adipose tissue, endothelial cells, and visceral fat stromal–vascular cells. It has anti-inflammatory effect and circulating omentin-1 concentration correlates negatively with waist circumference, insulin resistance, and body-mass index. Serum omentin-1 is used as a biomarker of coronary artery disease, obesity, cancer, metabolic syndrome, inflammatorydisease, atherosclerosis, and diabetes mellitus. The aim of our study is to investigate circulating omentin-1 levels in HT patients compared to healthy normotensive controls. Patients diagnosed with new essential HT (n = 61) and healthy normotensive individuals (n = 60) were enrolled in this study. The HT group was separated into two subgroups. There were 30 patients in stage 2 HT group and 31 patients in stage 1 HT group. Omentin-1 levels were significantly lower both in stage 1 and 2 HT subgroup as compared with the normotensive controls (72.19 ± 54.33 ng/ml for stage 1 HT subgroup; 62.45 ± 47.01 ng/ml for stage 2 HT subgroup; and, 147.84 ± 58.55 ng/ml for healthy normotensive controls; overall P < 0.001). The present study demonstrated that serum Omentin-1 levels decreased in patients with HT compared with normotensive controls. These lower concentrations may be attributed to a combined outcome of endothelial dysfunction, renal injury, and inflammation in the setting of hypertension.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Blüher M, Mantzoros CS. From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century. Metabolism. 2015;64:131–45. Epub 2014 Oct 23. PMID: 25497344

    Article  Google Scholar 

  2. Sahin-Efe A, Katsikeris F, Mantzoros CS. Advances in adipokines. Metabolism. 2012;61:1659–65.

    Article  CAS  Google Scholar 

  3. Blüher M. Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes. 2009;117:241–50.

    Article  Google Scholar 

  4. Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, et al. Identification of omentin as a novel depot specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab. 2006;290:1253–61.

    Article  Google Scholar 

  5. De Souza Batista CM, Yang RZ, Lee MJ, Glynn NM, Yu DZ, Pray J, et al. Omentin plasma levels and gene expression are decreased in obesity. Diabetes. 2007;56:1655–61.

    Article  Google Scholar 

  6. Onur I, Oz F, Yildiz S, Kuplay H, Yucel C, Sigirci S, et al. A decreased serum omentin-1 levelmay be an independent risk factor for peripheral arterial disease. Int Angiol. 2014;33:455–460.

    CAS  PubMed  Google Scholar 

  7. Yin J, Hou P, Wu Z, Nie Y. Decreased levels of serum omentin-1 in patients with inflammatory bowel disease. Med Sci Monit. 2015;21:118–122.

    Article  CAS  Google Scholar 

  8. Kocijancic M, Vujicic B, Racki S, Cubranic Z, Zaputovic L, Dvornik S. Serum omentin-1 levels as a possible risk factor of mortality in patients with diabetes on haemodialysis. Diabetes Res Clin Pract. 2015;110:44–50.

    Article  CAS  Google Scholar 

  9. Kannel WB. Blood pressure as a cardiovascular risk factor: prevention and treatment. J Am Med Assoc. 1996;275:1571–6.

    Article  CAS  Google Scholar 

  10. Bautista LE, Vera LM, Arenas IA, Gamarra G. Independent as-sociation between inflammatory markers (C-reactive protein, interleukin-6, and TNF alpha) and essential hypertension. J Hum Hypertens. 2005;19:149–54.

    Article  CAS  Google Scholar 

  11. Panza JA, Casino PR, Kilcoyne CM, Quyyumi AA. Role of endothelium-derived nitricoxide in the abnormal endothelium dependent vascular relaxation of patients with essential hypertension. Circulation. 1993;87:1468–74.

    Article  CAS  Google Scholar 

  12. Mattoo TK. Definition and diagnosis of hypertension in children and adolescents. In: UpTo Date. Stapleton FB, Fulton DR, Kim MS, eds. Waltham, MA: UpTo Date; 2009. http://www.uptodateonline.com/online/content/topic.do? topicKey=pedineph/11964&view=print. Accessed 8 Aug 2009.

  13. Lau DCW, Dhillon B, Yan HY, Szmitko PE, Verma S. Adipokines: molecular links between obesity and atheroslcerosis. Am J Physiol-Heart C 2005;288:2031–41.

    Article  Google Scholar 

  14. Fantuzzi G, Mazzone T. Adipose tissue and atherosclerosis: exploring the connection. Arterioscler Thromb Vasc Biol. 2007;27:996–1003.

    Article  CAS  Google Scholar 

  15. Steffens S, Mach F. Adiponectin and adaptive immunity: linking the bridge from obesity to atherogenesis. Circ Res. 2008;102:140–2.

    Article  CAS  Google Scholar 

  16. Watanabe T, Watanabe KK, Takahashi Y, Kojima M, Watanabe R. Adipose tissue-derived omentin-1 function and regulation 2017 American Physiological Society. Compr Physiol. 2017;7:765–81.

    Article  Google Scholar 

  17. Yamawaki H, Tsubaki N, Mukohda M, Okada M, Hara Y. Omentin, a novel adipokine,induces vasodilation in rat isolated blood vessels. Biochem Biophys Res Commun. 2010;393:668–72.

    Article  CAS  Google Scholar 

  18. Yamawaki H, Kuramoto J, Kameshima S, Usui T, Okada M, Hara Y. Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells. Biochem Biophys Res Commun. 2011;408:339–43.

    Article  CAS  Google Scholar 

  19. Mehaffey E, Majid DSA. Tumor necrosis factor-α, kidney function, and hypertension. Am J Physiol Ren Physiol. 2017;313(Oct):1005–8.

    Article  Google Scholar 

  20. TAliasghari F, Izadi A, Jabbari M, Imani B, Gargari BP, Asjodi F, et al. Are vaspin and omentin-1 related to insulin resistance. Blood Press Inflamm NAFLD Patients? J MedBiochem. 2018;37(Dec):470–5.

    CAS  Google Scholar 

  21. Moreno-Navarrete JM, Ortega F, Castro A, Sabater M, RicartW, Fern´andez-Real JM. Circulating omentin as a novel biomarker of endothelial dysfunction. Obesity. 2011;19:1552–9.

    Article  CAS  Google Scholar 

  22. Kadoglou NP, Lambadiari V, Gastounioti A, Gkekas C, GiannakopoulasTG, Koulia K, et al. The relationship of novel adipokines, RBP4 and omentin-1, with carotid atherosclerosis severity and vulnerability. Atherosclerosis. 2014;235:606–12.

    Article  CAS  Google Scholar 

  23. Onur I, Oz F, Yildiz S, Kuplay H, Yucel C, Sigirci S, et al. A decreased serum omentin-1 levelmay be an independent risk factor for peripheral arterial disease. Int Angiol. 2014;33:455–60.

    CAS  PubMed  Google Scholar 

  24. Xu T, Zuo P, Cao L, Gao Z, Ke K. Omentin-1 is associated with carotid plaque instability among ischemic stroke patients. J Atheroscler Thromb. 2018;25:505–11.

    Article  CAS  Google Scholar 

  25. Shibata R, Ouchi N, Kikuchi R, Takahashi R, Takeshita K, Kataoka Y, et al. Circulating omentin is associated with coronary artery disease in men. Atherosclerosis. 2011;219:811–4.

    Article  CAS  Google Scholar 

  26. Narumi T, Watanabe T, Kadowaki S, Kinoshita D, Yokoyama M, Honda Y, et al. Impact of serum omentin-1 levels on cardiac prognosis inpatients with heart failure. Cardiovasc Diabetol. 2014;13:84.

    Article  Google Scholar 

  27. Ku E, Lee BJ, Wei J, Weir MR. Hypertension in CKD: core curriculum 2019. Am J Kidney Dis. 2019;74:120–131.

    Article  Google Scholar 

  28. Yu Z, Rebholz CM, Wong E, Chen Y, Matsushita K, Coresh, et al. Association between hypertension and kidney function decline: the Atherosclerosis Risk in Communities (ARIC) study. Am J Kidney Dis. 2019;74:310–319.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiology, Ahi Evran University Training and Research Hospital, Kirsehir, Turkey

    Mustafa Çelik & Erdoğan Sökmen

  2. Department of Biochemistry, Pamukkale Medical Faculty, Denizli, Turkey

    Rukiye Nar

  3. Department of Cardiology, Pamukkale Medical Faculty, Denizli, Turkey

    Gökay Nar

  4. Department of Biostatistics, Istanbul Medical Faculty, İstanbul, Turkey

    Güven Günver

Authors
  1. Mustafa Çelik
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rukiye Nar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gökay Nar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Erdoğan Sökmen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Güven Günver
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mustafa Çelik.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Çelik, M., Nar, R., Nar, G. et al. Serum omentin-1 levels in hypertensive patients. J Hum Hypertens 35, 290–295 (2021). https://doi.org/10.1038/s41371-020-00420-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41371-020-00420-4

This article is cited by

Search

Advanced search

Quick links