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Adipokines: another link between obesity and hypertension

Journal of Human Hypertension volume 29, page 210 (2015)Cite this article

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We have read the interesting review entitled ‘A critical review of the evidence supporting aldosterone in the etiology and its blockade in the treatment of obesity-associated hypertension’.1 This article reviews with great background concepts about obesity, aldosterone and hypertension. However, there is no mention about adipokines—bioactive mediators produced by adipose tissue2—and its association in the link obesity/hypertension.3, 4, 5

As we know, higher aldosterone levels in obese subjects may be relevant as a complicating factor for the lack of blood pressure (BP) control3, 6 and as a mediator of maladaptive changes associated with cardiovascular abnormalities.3 Lipid factors seem to stimulate aldosterone secretion4 in mineralocorticoid receptor on adipose tissue, which in turn activates proinflammatory adipokine expression.5 Those conditions may contribute to mechanisms related to the development of resistant hypertension (RHTN).

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References

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  8. de Faria AP, Demacq C, Figueiredo VN, Moraes CH, Santos RC, Sabbatini AR et al. Hypoadiponectinemia and aldosterone excess are associated with lack of blood pressure control in subjects with resistant hypertension. Hypertens Res 2013; 36 (12): 1067–1072.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medical Sciences University of Campinas—UNICAMP, Campinas, Brazil

    A R Sabbatini, A P C de Faria, R Modolo & H Moreno

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  1. A R Sabbatini
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  2. A P C de Faria
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  3. R Modolo
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  4. H Moreno
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Correspondence to H Moreno.

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Sabbatini, A., de Faria, A., Modolo, R. et al. Adipokines: another link between obesity and hypertension. J Hum Hypertens 29, 210 (2015). https://doi.org/10.1038/jhh.2014.28

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