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Hypertensive epigenetics: from DNA methylation to microRNAs

Journal of Human Hypertension volume 29, pages 575–582 (2015)Cite this article

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Abstract

The major epigenetic features of mammalian cells include DNA methylation, posttranslational histone modifications and RNA-based mechanisms including those controlled by small non-coding RNAs (microRNAs (miRNAs)). An important aspect of epigenetic mechanisms is that they are potentially reversible and may be influenced by nutritional–environmental factors and through gene–environment interactions. Studies on epigenetic modulations could help us understand the mechanisms involved in essential hypertension and further prevent it’s progress. This review is focused on new knowledge on the role of epigenetics, from DNA methylation to miRNAs, in essential hypertension.

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Acknowledgements

The study was supported by the Ministry of Science and Technology of China with ‘973’ grant 2012CB517804 and the National Natural Science Foundation of China with grants 81322002 and 81270333 to Dr Wang.

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  1. State Key Laboratory of Cardiovascular Disease, Sino-German Laboratory for Molecular Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    J Wang, L Gong, Y Tan, R Hui & Y Wang

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Wang, J., Gong, L., Tan, Y. et al. Hypertensive epigenetics: from DNA methylation to microRNAs. J Hum Hypertens 29, 575–582 (2015). https://doi.org/10.1038/jhh.2014.132

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