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The prevalence of metabolic syndrome and its components in two main types of primary aldosteronism

Journal of Human Hypertension volume 24, pages 625–630 (2010)Cite this article

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Abstract

Metabolic syndrome (MS) is frequent clinical condition in patients with hypertension. Primary aldosteronism (PA) is a common form of secondary hypertension. This study was aimed at investigating the prevalence of the MS and its components in the two major forms of PA, in unilateral aldosterone-producing adenoma (APA) and bilateral aldosterone overproduction because of idiopathic hyperaldosteronism (IHA). The diagnosis of the particular form of PA was based on adrenal venous sampling and/or successful surgery confirmed by histopathological examination. We analyzed clinical and laboratory data from 100 patients with PA (50 patients with IHA and 50 patients with APA) and from 90 patients with essential hypertension (EH). Metabolic profiles of patients with bilateral form of PA (because of IHA) were similar to EH, but differed from those in patients with unilateral form of PA (APA). The prevalence of the MS (62% in IHA, 34% in APA and 56% in EH), the body mass index value (30±4 kg m–2 in IHA, 27±5 kg m–2 in APA and 29±5 kg m–2 in EH) and triglycerides levels (1.9±0.9 mmol l–1 in IHA,1.4±0.8 mmol l–1 in APA and 2.01±1.39 mmol l–1 in EH) were all significantly (P<0.05) higher in IHA compared with APA patients. Metabolic profile of patients with bilateral form of PA (because of IHA) is similar to EH in contrast to unilateral form of PA (APA).

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Acknowledgements

This work was supported by Research projects from Czech Ministry of Education, Youth and Sports No: 21620807 and 21620817.

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Authors and Affiliations

  1. Third Department of Internal Medicine—Center for Hypertension, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

    Z Šomlóová, J Widimský jr, J Rosa, B Štrauch, O Petrák, T Zelinka, J Dvořáková & R Holaj

  2. Department of Cardiology and Angiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

    D Wichterle

  3. Department of Radiodiagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

    J Vlková & M Mašek

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  1. Z Šomlóová
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Correspondence to Z Šomlóová.

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Šomlóová, Z., Widimský, J., Rosa, J. et al. The prevalence of metabolic syndrome and its components in two main types of primary aldosteronism. J Hum Hypertens 24, 625–630 (2010). https://doi.org/10.1038/jhh.2010.65

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