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Seasonal variation in haemodynamics and blood pressure-regulating hormones

Journal of Human Hypertension volume 24, pages 410–416 (2010)Cite this article

Abstract

Seasonal variation in blood pressure (BP) has been described in some people, although the variation is small for both systolic and diastolic BPs. The aim of this study was to elucidate underlying haemodynamic and hormonal mechanisms that may occur to defend seasonal changes in BP. Participants were 27 men and 7 women with either normal BP or early hypertension. Measurements of haemodynamics (cardiac output by dual-gas rebreathing) and hormones (resting catecholamines, renin activity, and aldosterone by radioenzymatic assay or radioimmunoassay) were performed during the summer, fall, winter, and spring seasons. Student's paired t-test with Bonferroni modification and regression analyses were used to examine the data with a significance level of P<0.05. Systolic and diastolic BP remained relatively constant across seasons. Cardiac output and stroke volume significantly decreased 10 and 15%, respectively, from summer to winter, whereas heart rate and systemic vascular resistance significantly increased 5 and 11%, respectively. Plasma aldosterone (PA) significantly increased 59% from summer to winter, whereas plasma norepinephrine (PNE), plasma epinephrine, and plasma renin activity (PRA) increased 19, 2, and 17%, respectively (pNS for each). Across the four seasons, mean arterial pressure significantly correlated with PRA and PA, whereas systemic vascular resistance significantly correlated with PNE and PRA. There are dramatic counterregulatory haemodynamic and hormonal adaptations to maintain a relatively constant BP. Norepinephrine, PRA, and aldosterone have a function in mediating the changes in haemodynamics.

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Acknowledgements

We thank Pat Larrabee, MS, RN, project coordinator, and Wu, Yow-Wu, PhD, for statistical consultation. This study was supported, in part, by a grant from the New York State Affiliate of the American Heart Association.

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Authors and Affiliations

  1. Department of Medicine, Erie County Medical Center, Buffalo, NY, USA

    K J Radke & J L Izzo Jr

  2. and Department of Physiology and Biophysics, School of Nursing, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA

    K J Radke

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  1. K J Radke
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  2. J L Izzo Jr
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Correspondence to K J Radke.

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Competing interests

Dr Radke declares no conflict of interest. Dr Izzo has potential conflict of interest in that he has been funded by Novartis, GlaxcoSmithKline, and Daiichi/Sankyo. Moreover, he has received compensation as a consultant and/or speaker for Merck, Medical Education Consultants, Novartis, GlaxoSmithKline, SCS Healthcare, Daiichi/Sankyo, and Medplan.

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Radke, K., Izzo, J. Seasonal variation in haemodynamics and blood pressure-regulating hormones. J Hum Hypertens 24, 410–416 (2010). https://doi.org/10.1038/jhh.2009.75

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