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The purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene associated with essential hypertension in Japanese men

Journal of Human Hypertension volume 24, pages 327–335 (2010)Cite this article

Abstract

P2RY2 has an important function in the regulation of blood pressure by activating adenosine triphosphate (ATP). The aim of this study was to investigate the association between the human P2RY2 gene and essential hypertension (EH) through a haplotype-based case–control study that included two gender groups. The 273 EH patients and 255 age-matched controls were genotyped for five single-nucleotide polymorphisms (SNPs) of the human P2RY2 gene (rs4944831, rs1783596, rs4944832, rs4382936 and rs10898909). Data were analysed for men and women separately and then as a combined total group. For the total and the men only groups, the genotype distribution of the T allele of rs4944831 and the recessive model (GG vs TG+TT) of rs4944831 differed significantly between the EH patients and controls (P=0.028 and 0.019; P=0.009 and 0.008, respectively). Logistic regression showed that for the total and men groups, the TG+TT genotype of rs4944831 was more prevalent in EH patients than in the controls (P=0.026 and 0.011, respectively). For men, the overall distribution of the haplotype (SNP2-SNP4-SNP5) was significantly different between the EH patients and the controls (P=0.006). As compared with controls, the frequency of the T-A-G haplotype was significantly higher, whereas the T-C-G haplotype was significantly lower for the EH patients (P=0.001 and 0.014, respectively). In conclusion, the present results indicate that rs4944831 and the T-A-G haplotype of the human P2RY2 gene might be genetic markers for EH in Japanese men.

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Acknowledgements

We thank Ms K Sugama for her excellent technical assistance. This work was supported by grants from Toray Co, Ltd and the Ministry of Education, Culture, Sports, Science and Technology of Japan (High-Tech Research Center, Nihon University).

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Authors and Affiliations

  1. Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan

    Z Wang, T Nakayama, N Sato & N Aoi

  2. Department of Cardiovascular Medicine, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, PR China

    Z Wang & Y Ma

  3. Division of Nephrology, Department of Medicine, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan

    T Nakayama & Y Izumi

  4. Division of Cardiovascular Medicine, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan

    Y Kasamaki, M Ohta & Y Ozawa

  5. Division of General Medicine, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan

    M Soma

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  1. Z Wang
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Correspondence to T Nakayama.

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Wang, Z., Nakayama, T., Sato, N. et al. The purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene associated with essential hypertension in Japanese men. J Hum Hypertens 24, 327–335 (2010). https://doi.org/10.1038/jhh.2009.67

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