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Losartan decreased premature ventricular contractions in patients with hypertension

Journal of Human Hypertension volume 23, pages 289–291 (2009)Cite this article

Losartan, enalapril and amlodipine reduced the number of premature ventricular contractions (PVCs) in patients with essential hypertension as well as blood pressure. The effect of losartan was the most prominent among the three drugs.

Premature ventricular contractions have been recognized as a marker of remodelled hypertensive heart. The prognosis of the patients with hypertension was better when they had no PVC in the ambulatory electrocardiogram (ECG).1, 2, 3, 4 Fibrosis and hypertrophy due to hypertension, which constitute a substrate of PVCs, could regress after the administration of antihypertensive drugs.5 Whether antihypertensive drugs could decrease PVC is not known. In this study, we investigated whether losartan, enalapril and amlodipine could reduce PVC in hypertensive patients.

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Authors and Affiliations

  1. Department of Cardiology and Vascular Regenerative Medicine, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan

    H Shiraishi, T Shirayama, T Sakamoto, A Kuroyanagi & H Matsubara

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  1. H Shiraishi
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  2. T Shirayama
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  3. T Sakamoto
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  4. A Kuroyanagi
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  5. H Matsubara
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Correspondence to T Shirayama.

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Shiraishi, H., Shirayama, T., Sakamoto, T. et al. Losartan decreased premature ventricular contractions in patients with hypertension. J Hum Hypertens 23, 289–291 (2009). https://doi.org/10.1038/jhh.2008.122

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