Summary
A factor B subtype, BF*Fb1, was first detected in Japanese by using isoelectric focusing or agarose gel electrophoresis in Tris/glycine/Veronal buffer. Our previous studies suggested that BF*Fb1 may be characteristic of some of Mongoloid populations. To investigate further distribution of BF*Fb1, samples randomly collected from Japanese in Yonaguni island of Japan and Cambodian were tested. BF*Fb1 was not observed in a Cambodian population whereas in a Japanese population of Yonaguni island, BF*Fb1 occurred at a frequency five times as high as those in main islands of Japan. In paternity cases, a Korean family with three offsprings was shown to transmit BF*Fb1 from the accused man to one of the offsprings. These data strongly indicate that BF*Fb1 is a marker gene for some of Mongoloid populations.
Similar content being viewed by others
Article PDF
References
Abbal, M., Thomsen, M., Cambon-Thomsen, A., Archambeau, J., Calot, M. and Fatallah, D. 1985. Two subtypes of BfF by isoelectrofocusing: Differential linkage to other HLA markers.Hum. Genet. 69: 181–183.
Alper, C.A., Boenisch, R. and Watson, L. 1972. Genetic polymorphism in human glycine-rich beta-glycoprotein.J. Exp. Med. 135: 68–80.
Carroll, M.C., Campbell, R.D., Bentley, D.R. and Porter, R.R. 1984. A molecular map of the human major histocompatibility complex class III region lining complement genes C4, C2 and factor B.Nature 307: 237–241.
Carroll, M.C., Campbell, R.D. and Porter, R.R. 1985. The mapping of 21-hydroxylase genes adjacent to complement component C4 genes in HLA, the major histocompatibility complex in man.Proc. Natl. Acad. Sci. U.S.A. 82: 521–525.
Constans, J., Hazout, R.M., Garruto, D.C., Gajdusek, D.C. and Spees, E.K. 1985. Population distribution of the human vitamin D binding protein: Anthropological considerations.Am. J. Phys. Anthropol. 68: 107–122.
David, V., Fauchet, R., Phengsavath, H., Guenet, L. and Le Gall, J.Y. 1983. Properdin factor B (Bf) polymorphism: Subtyping of SS phenotypes.Hum. Genet. 64: 189–190.
Geserick, G., Patzelt, D., Schroder, H. and Nagai, T. 1983. Isoelectrofocusing in the study of the Bf system: Existence of two common subtypes of the BfF allele.Vox Sang. 44: 178–182.
Geserick, G. and Patzelt, D. 1988. Factor B(BF) subtyping by isoelectric focusing: Methods, nomenclature, genetics and forensic application.Electrophoresis 8: 418–422.
Geserick, G., Rose, M., Martin, W. and Schroder, H. 1989. Detection of a new BF F subtype variant by isoelectric focusing.Exp. Clin. Immunogenet. 6: 156–161.
Greiner, J., Weber, F.J., Mauff, G. and Baur, M. 1980. Genetic polymorphisms of properdin factor B (Bf), the second component (C2), and the fourth component (C4) of complement in leprosy patients and healthy controls from Thailand.Immunobiology 158: 134–138.
Horai, S. 1976. Genetic polymorphism of human serum factor B (Bf) in Japanese.Jpn. J. Human Genet. 21: 177–186.
Kamboh, M.I. and Ferrell, R.E. 1987. Human transferrin polymorphism.Hum. Hered. 37: 65–81.
Layrisse, M., Arends, T. and Dominguez, S.R. 1955. Nuevo group sanguineo encontrado en descendientes de Indios.Acta Medica Venezolana 3: 132–138.
Luo, Z., Du, C., Tokunaga, K. and Omoto, K. 1987. Genetic polymorphism of properdin factor B (BF) in a Chinese population: Existence of two rare variants.Jpn. J. Human Genet. 32: 33–38.
Matsumoto, H. 1988. Characteristics of Mongoloid and neighboring populations based on the genetic markers of human immunoglobulins.Hum. Genet. 80: 207–218.
Miyano, M., Nanjo, K., Okai, K., Sowa, R., Nomura, Y., Kondo, T., Sanke, T., Kawa, A., Miyamura, K., Aiyathurai, E., Ferunando, R. and Vichayanrat, A. 1986. Properdin factor B frequencies in four Asian populations.Hum. Hered. 36: 129–131.
Müller-Eberhard, H.J. 1988. Molecular organization and function of the complement system.Annu. Rev. Biochem. 57: 321–347.
Nagai, T., Nagai, T. and Ikeda, T. 1986. Isoelectrofocusing in the study of the BfF system: Existence of two common subtypes of the BfF allele in a Japanese population.Forensic Sci. Int. 30: 79–82.
Nakamura, S., Ohue, O. and Abe, K. 1987. A new BF F variant by polyacrylamide gel isoelectric focusing.Hum. Genet. 77: 295–296.
Nishimukai, H. 1982. Studies on genetic polymorphisms of C3 and factor B (Bf) in Japanese.J. Kyoto Pref. Univ. Med. 91: 1177–1202.
Nishimukai, H., Nakanishi, I., Kitamura, H. and Tamaki, Y. 1988. Factor B subtypes in Japanese patients with IgA nephropathy and with idiopathic membranous nephropathy.Exp. Clin. Immunogenet. 5: 196–202.
O'Neill, G.J., Yang, S.Y. and Dupont, B. 1978. Two HLA-linked loci controlling the fourth component of human complement.Proc. Natl. Acad. Sci. U.S.A. 75: 5165–5169.
Park, K.S., Tokunaga, K. and Omoto, K. 1985. Genetic polymorphisms of complement components BF and C2 in Korean: Population and association studies.Jpn. J. Human Genet. 30: 9–14.
Raum, D., Surgenor, T., Awdeh, Z., Marcus, M., Blumenthal, M., Yunis, E.J. and Alper, C.A. 1984. An unusual “Morphologic” variant of BF S.Am. J. Hum. Genet. 36: 346–351.
Segurado, O.G. and Arnaiz-Villena, A. 1989. Two BF F subtypes, but no BF S, BF F1 or BF S07 subdivision, are found by isoelectric focusing.Vox Sang. 56: 117–121.
Sim, E. and Cross, J. 1986. Phenotyping of human complement protein C4, a class III HLA antigen.Biochem. J. 239: 762–767.
Suzuki, K., Matsumoto, H., Matsuo, Y., Shoda, K., Iwata, M. and O'Neill, G.J. 1986. Genetic polymorphisms of human complement components in Japanese and their application to parentage testing. InAdvances in Forensic Haemogenetics 1. Brinkman, B. and Henningsen, K., eds., Springer-Verlag, Berlin and Heidelberg, pp. 80–84.
Suzuki, K., Harumoto, T., Ito, S. and Matsumoto, H. 1987a. Subtyping of factor B by agarose gel electrophoresis.Electrophoresis 8: 481–485.
Suzuki, K., Charoenwongse, P., Lingao, A.L., Contractor, N.M., Matsushita, S., Sasazuki, T. and Matsumoto, H. 1987b. Factor B polymorphism in four Asian populations: Electrophoretic characterization of a subtype of “F” and of new variants in the Chinese.Electrophoresis 8: 486–489.
Suzuki, K., Ito, S., Tamura, A., Fujita, K. and Matsumoto, H. 1989. Hereditary subtypic patterns detected in the Ba fragment of complement factor B: Occurrence of four common alleles in Japanese. (submitted toElectrophoresis)
Teng, Y.S. and Tan, S.G. 1982. Subtyping of properdin factor B (Bf) by isoelectrofocusing.Hum. Hered. 32: 362–366.
Tokunaga, K., Araki, C., Juji, T. and Omoto, K. 1982. Polymorphism of properdin factor B in Japanese. Description of a rare variant and data of association with HLA and C2.Hum. Genet. 60: 42–45.
Weidinger, S., Schwarzfischer, F., Burgemeister, T. and Cleve, H. 1984. Two new BfS subtypes revealed by isoelectric focusing and immunofixation.Hum. Genet. 68: 90–92.
White, P.C., Grossberger, D., Onufer, B.J., Chaplin, D.D. and New, M.I. 1985. Two genes encoding steroid 21-hydroxylase and located near the genes encoding the fourth component of complement in man.Proc. Natl. Acad. Sci. U.S.A. 82: 1089–1093.
Zhao, T. 1983. Genetic polymorphisms of C3 and Bf in the Chinese population.Hum. Hered. 33: 36–38.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Suzuki, K., Mutoh, S., Cey-Bert, G. et al. A BF subtype “Fb1” is a marker gene of some mongoloid populations. Jap J Human Genet 35, 169–177 (1990). https://doi.org/10.1007/BF01876462
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01876462