Summary
An autosomal doubly recessive mode of inheritance was implemented in segregation analysis, taken into account for segregation frequency, proportion of sporadic cases and ascertainment probability. Maximum likelihood scores are tabulated for some sizes of sibship. Segregation analysis thus becomes much easier with a desk calculator. The procedure has been illustrated for Graves disease.
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Yasuda, N., Sasazuki, T. Complex segregation analysis for two-locus model: Autosomal double recessive. Jap J Human Genet 29, 421–435 (1984). https://doi.org/10.1007/BF01876500
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DOI: https://doi.org/10.1007/BF01876500
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