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Ghanamycins A and B, two novel γ-butyrolactones from marine-derived streptomyces ghanaensis TXC6-16

The Journal of Antibiotics volume 70, pages 733736 (2017) | Download Citation

Abstract

Two novel γ-butyrolactones ghanamycins A (1) and B (2) were isolated from the fermentation broth of marine-derived Streptomyces ghanaensis TXC6-16. Their structures were elucidated by spectroscopic analysis. These two novel compounds exhibited antimicrobial activities against some phytopathogens. The minimum IC (MIC) of 2 against Pseudomonas syringae and Erwinia sp. were 50 μg ml−1.

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Acknowledgements

This work was financially supported by the High-Tech Program (863 Program) of China (2008AA09Z407), National Natural Science Foundation of China No. 40776098 and 40976104, and the National Special Fund for State Key Laboratory of Bioreactor Engineering, Grant No 2060204.

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Affiliations

  1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China

    • Jia-hui Xu
    • , Kang-bo Gu
    • , Dao-Jing Zhang
    •  & Yuan-Guang Li
  2. First Institute of Oceanography, State Oceanic Administration, Qingdao, China

    • Li Tian

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Competing interests

All authors contributed equally to this work and declare no conflict of interest.

Corresponding authors

Correspondence to Dao-Jing Zhang or Yuan-Guang Li.

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DOI

https://doi.org/10.1038/ja.2017.37

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