Original Article | Published:

Pestalols A–E, new alkenyl phenol and benzaldehyde derivatives from endophytic fungus Pestalotiopsis sp. AcBC2 isolated from the Chinese mangrove plant Aegiceras corniculatum

The Journal of Antibiotics volume 67, pages 451457 (2014) | Download Citation

Abstract

Five alkenyl phenol and benzaldehyde derivatives, pestalols A-E (15), as well as seven known compounds (612), were isolated from endophytic fungus Pestalotiopsis sp. AcBC2 derived from the Chinese mangrove plant Aegiceras corniculatum. Their structures were determined by spectroscopic analyses. Compounds 2 and 3 showed cytotoxicity against a panel of 10 tumor cell lines. Compounds 15, 8, 9, 11, and 12 showed inhibitory activities against Influenza A virus subtype (H3N2) and Swine Flu (H1N1) viruses. Compound 2 also showed inhibitory activity against tuberculosis.

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Acknowledgements

This study was supported by the National Basic Research Program of China (973 Program, Nos. 2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), the National Natural Science Foundation of China (Nos. 31270402, 21172230, 20902094, 41176148 and 21002110), the Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264) and the Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002).

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Author notes

    • Jian-Fan Sun
    •  & Xiuping Lin

    These authors contributed equally to this work.

Affiliations

  1. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, People’s Republic of China

    • Jian-Fan Sun
    • , Xiuping Lin
    • , Xue-Feng Zhou
    • , Bin Yang
    • , Xian-Wen Yang
    •  & Yonghong Liu
  2. School of Environment, Jiangsu University, Zhenjiang, People’s Republic of China

    • Jian-Fan Sun
  3. State Key Laboratory of Respiratory Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People’s Republic of China

    • Junting Wan
    • , Tianyu Zhang
    •  & Zhengchao Tu

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Competing interests

The authors declare no conflict of interest.

Corresponding authors

Correspondence to Zhengchao Tu or Yonghong Liu.

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DOI

https://doi.org/10.1038/ja.2014.24

Supplementary Information accompanies the paper on The Journal of Antibiotics website (http://www.nature.com/ja)

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