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New butyrolactone derivatives from the endophytic Fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt

The Journal of Antibiotics volume 74, pages 225–232 (2021)Cite this article

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Abstract

Six new butyrolactone derivatives (1, 2a/2b, 3a/3b and 4), together with another two known derivatives (5 and 6) were isolated from the endophytic fungus Talaromyces sp. CPCC 400783. Their structures were established by a combination of spectroscopic analysis, including NMR and HRESIMS. The absolute configurations were elucidated by ECD experiments. Subsequently, compound 1, 3b, 4 and 5 exhibited good inhibitory effect against influenza A/WSN/33 (H1N1) virus with IC50 values of 21.93 ± 1.51, 21.54 ± 3.75, 18.36 ± 2.15 and 23.80 ± 3.05 μM respectively.

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Acknowledgements

This work was financially supported by the Drug Innovation Major Project (2018ZX09711001-007-001), the National Natural Science Foundation of China (No. 81973220), CA and MS Innovation Fund for Medical Sciences (No. 2016-I2M-2-002, 2016-I2M-2-003 and 2020-I2M-2-010), the National Microbial Resource Center (No. NMRC-2020-3) and Practical training plan for cross training of high level talents in Beijing Universities (No. 2018-160).

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  1. These authors contributed equally: Ran Zhang, Wenni He

Authors and Affiliations

  1. China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

    Ran Zhang, Wenni He & Liyan Yu

  2. Immunology Division, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

    Yujia Wang, JianYuan Zhao, Rui Zhou & Shan Cen

  3. Department of Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

    Li Li

  4. College of Biochemical Engineering, Beijing Union University, Beijing, 100101, China

    Yize He

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  1. Ran Zhang
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Correspondence to Liyan Yu.

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Zhang, R., He, W., Wang, Y. et al. New butyrolactone derivatives from the endophytic Fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt. J Antibiot 74, 225–232 (2021). https://doi.org/10.1038/s41429-020-00388-w

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